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3bkv

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{{STRUCTURE_3bkv| PDB=3bkv | SCENE= }}
{{STRUCTURE_3bkv| PDB=3bkv | SCENE= }}
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'''X-ray structure of the bacteriophage phiKZ lytic transglycosylase, gp144, in complex with chitotetraose, (NAG)4'''
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===X-ray structure of the bacteriophage phiKZ lytic transglycosylase, gp144, in complex with chitotetraose, (NAG)4===
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==Overview==
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Lytic transglycosylases are enzymes which act on the peptidoglycan of bacterial cell walls. They cleave the glycosidic linkage between N-acetylmuramoyl and N-acetylglucosaminyl residues with the concomitant formation of a 1,6-anhydromuramoyl product. The X-ray structure of the lytic transglycosylase, gp144, from the Pseudomonas bacteriophage phiKZ, has been determined to 2.5 A resolution. This protein is probably employed by the bacteriophage in the late stage of the virus reproduction cycle to destroy the bacterial cell wall to release the phage progeny. The phiKZ gp144 is a 260 residue a-helical protein composed of a 70-residue N-terminal cell wall binding domain and a C-terminal catalytic domain. The fold of the N-terminal domain is similar to the peptidoglycan binding domain from Streptomyces albus G D-Ala-D-Ala carboxypeptidase and to the N-terminal pro-domain of human metalloproteinases that act on extracellular matrices. The C-terminal catalytic domain of gp144 has a structural similarity to the catalytic domain of the transglycosylase SLT70 from E. coli and to lysozymes. The gp144 catalytic domain has an elongated groove which can bind at least five sugar residues at sites A, B, C, D, and E. As in other lysozymes, the peptidoglycan cleavage, catalyzed by Glu 115 in gp144, occurs between the sugar-binding subsites D and E. The X-ray structure of the phiKZ transglycosylase has been determined to 2.6 A resolution when complexed with the chitotetraose (NAG)(4). The NAG residues of the chitotetraose bind in sites A through D.
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{{ABSTRACT_PUBMED_18160394}}
==About this Structure==
==About this Structure==
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[[Category: Transferase]]
[[Category: Transferase]]
[[Category: Transglycosylase]]
[[Category: Transglycosylase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 23 10:02:04 2008''

Revision as of 07:02, 23 July 2008

Image:3bkv.png

Template:STRUCTURE 3bkv

X-ray structure of the bacteriophage phiKZ lytic transglycosylase, gp144, in complex with chitotetraose, (NAG)4

Template:ABSTRACT PUBMED 18160394

About this Structure

3BKV is a Single protein structure of sequence from Pseudomonas phage phikz. Full crystallographic information is available from OCA.

Reference

Structure of the bacteriophage phiKZ lytic transglycosylase, gp144., Fokine A, Miroshnikov KA, Shneider MM, Mesyanzhinov VV, Rossmann MG, J Biol Chem. 2007 Dec 26;. PMID:18160394

Page seeded by OCA on Wed Jul 23 10:02:04 2008

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