2gtv

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[[Image:2gtv.jpg|left|200px]]
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{{STRUCTURE_2gtv| PDB=2gtv | SCENE= }}
{{STRUCTURE_2gtv| PDB=2gtv | SCENE= }}
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'''NMR structure of monomeric chorismate mutase from Methanococcus jannaschii'''
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===NMR structure of monomeric chorismate mutase from Methanococcus jannaschii===
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==Overview==
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Although protein dynamics has been recognized as a potentially important contributor to enzyme catalysis, structural disorder is generally considered to reduce catalytic efficiency. This widely held assumption has recently been challenged by the finding that an engineered chorismate mutase combines high catalytic activity with the properties of a molten globule, a loosely packed and highly dynamic conformational ensemble. Taking advantage of the ordering observed upon ligand binding, we have now used NMR spectroscopy to characterize this enzyme in complex with a transition-state analog. The complex adopts a helix-bundle structure, as designed, but retains unprecedented flexibility on the millisecond timescale across its entire length. Moreover, pre-steady-state kinetics data show that binding occurs by an induced-fit mechanism on the same timescale as the enzymatic reaction, linking global conformational plasticity with efficient catalysis.
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(as it appears on PubMed at http://www.pubmed.gov), where 17994104 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17994104}}
==About this Structure==
==About this Structure==
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2GTV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GTV OCA].
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2GTV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GTV OCA].
==Reference==
==Reference==
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[[Category: Vogeli, B R.]]
[[Category: Vogeli, B R.]]
[[Category: Four-helix bundle]]
[[Category: Four-helix bundle]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:31:58 2008''
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[[Category: Isomerase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 23 10:03:23 2008''

Revision as of 07:03, 23 July 2008

Image:2gtv.png

Template:STRUCTURE 2gtv

NMR structure of monomeric chorismate mutase from Methanococcus jannaschii

Template:ABSTRACT PUBMED 17994104

About this Structure

2GTV is a Single protein structure of sequence from Methanocaldococcus jannaschii. Full experimental information is available from OCA.

Reference

Structure and dynamics of a molten globular enzyme., Pervushin K, Vamvaca K, Vogeli B, Hilvert D, Nat Struct Mol Biol. 2007 Dec;14(12):1202-6. Epub 2007 Nov 11. PMID:17994104

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