2zci

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{{STRUCTURE_2zci| PDB=2zci | SCENE= }}
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'''Structure of a GTP-dependent bacterial PEP-carboxykinase from Corynebacterium glutamicum'''
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===Structure of a GTP-dependent bacterial PEP-carboxykinase from Corynebacterium glutamicum===
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==Overview==
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GTP-dependent phosphoenolpyruvate carboxykinase (PCK) is the key enzyme that controls the blood glucose level during fasting in higher animals. Here we report the first substrate-free structure of a GTP-dependent phosphoenolpyruvate (PEP) carboxykinase from a bacterium, Corynebacterium glutamicum (CgPCK). The protein crystallizes in space group P2(1) with four molecules per asymmetric unit. The 2.3A resolution structure was solved by molecular replacement using the human cytosolic PCK (hcPCK) structure (PDB ID: 1KHF) as the starting model. The four molecules in the asymmetric unit pack as two dimers, and is an artifact of crystal packing. However, the P-loop and the guanine binding loop of the substrate-free CgPCK structure have different conformations from the other published GTP-specific PCK structures, which all have bound substrates and/or metal ions. It appears that a change in the P-loop and guanine binding loop conformation is necessary for substrate binding in GTP-specific PCKs, as opposed to overall domain movement in ATP-specific PCKs.
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{{ABSTRACT_PUBMED_18234538}}
==About this Structure==
==About this Structure==
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[[Category: Lyase]]
[[Category: Lyase]]
[[Category: Signaling protein]]
[[Category: Signaling protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 23 10:06:33 2008''

Revision as of 07:06, 23 July 2008

Image:2zci.png

Template:STRUCTURE 2zci

Structure of a GTP-dependent bacterial PEP-carboxykinase from Corynebacterium glutamicum

Template:ABSTRACT PUBMED 18234538

About this Structure

2ZCI is a Single protein structure of sequence from Corynebacterium glutamicum. Full crystallographic information is available from OCA.

Reference

Structure of a GTP-dependent Bacterial PEP-carboxykinase from Corynebacterium glutamicum., Aich S, Prasad L, Delbaere LT, Int J Biochem Cell Biol. 2007 Dec 23;. PMID:18234538

Page seeded by OCA on Wed Jul 23 10:06:33 2008

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