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3b8z

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{{STRUCTURE_3b8z| PDB=3b8z | SCENE= }}
{{STRUCTURE_3b8z| PDB=3b8z | SCENE= }}
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'''High Resolution Crystal Structure of the Catalytic Domain of ADAMTS-5 (Aggrecanase-2)'''
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===High Resolution Crystal Structure of the Catalytic Domain of ADAMTS-5 (Aggrecanase-2)===
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==Overview==
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Aggrecanase-2 (a disintegrin and metalloproteinase with thrombospondin motifs-5 (ADAMTS-5)), a member of the ADAMTS protein family, is critically involved in arthritic diseases because of its direct role in cleaving the cartilage component aggrecan. The catalytic domain of aggrecanase-2 has been refolded, purified, and crystallized, and its three-dimensional structure determined to 1.4A resolution in the presence of an inhibitor. A high resolution structure of an ADAMTS/aggrecanase protein provides an opportunity for the development of therapeutics to treat osteoarthritis.
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(as it appears on PubMed at http://www.pubmed.gov), where 17991750 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17991750}}
==About this Structure==
==About this Structure==
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[[Category: Alpha/beta]]
[[Category: Alpha/beta]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:32:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 23 10:09:37 2008''

Revision as of 07:09, 23 July 2008

Image:3b8z.png

Template:STRUCTURE 3b8z

High Resolution Crystal Structure of the Catalytic Domain of ADAMTS-5 (Aggrecanase-2)

Template:ABSTRACT PUBMED 17991750

About this Structure

3B8Z is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

High resolution crystal structure of the catalytic domain of ADAMTS-5 (aggrecanase-2)., Shieh HS, Mathis KJ, Williams JM, Hills RL, Wiese JF, Benson TE, Kiefer JR, Marino MH, Carroll JN, Leone JW, Malfait AM, Arner EC, Tortorella MD, Tomasselli A, J Biol Chem. 2008 Jan 18;283(3):1501-7. Epub 2007 Nov 8. PMID:17991750

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