2rjr

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[[Image:2rjr.jpg|left|200px]]
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{{Seed}}
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[[Image:2rjr.png|left|200px]]
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{{STRUCTURE_2rjr| PDB=2rjr | SCENE= }}
{{STRUCTURE_2rjr| PDB=2rjr | SCENE= }}
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'''Substrate mimic bound to SgTAM'''
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===Substrate mimic bound to SgTAM===
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==Overview==
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The synthesis and evaluation of two classes of inhibitors for SgTAM, a 4-methylideneimidazole-5-one (MIO) containing tyrosine aminomutase, are described. A mechanism-based strategy was used to design analogs that mimic the substrate or product of the reaction and form covalent interactions with the enzyme through the MIO prosthetic group. The analogs were characterized by measuring inhibition constants and X-ray crystallographic structural analysis of the co-complexes bound to the aminomutase, SgTAM.
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(as it appears on PubMed at http://www.pubmed.gov), where 18078753 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18078753}}
==About this Structure==
==About this Structure==
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[[Category: Isomerase]]
[[Category: Isomerase]]
[[Category: Mio]]
[[Category: Mio]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 17:03:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 23 10:14:50 2008''

Revision as of 07:14, 23 July 2008

Image:2rjr.png

Template:STRUCTURE 2rjr

Substrate mimic bound to SgTAM

Template:ABSTRACT PUBMED 18078753

About this Structure

2RJR is a Single protein structure of sequence from Streptomyces globisporus. Full crystallographic information is available from OCA.

Reference

Design and characterization of mechanism-based inhibitors for the tyrosine aminomutase SgTAM., Montavon TJ, Christianson CV, Festin GM, Shen B, Bruner SD, Bioorg Med Chem Lett. 2007 Nov 19;. PMID:18078753

Page seeded by OCA on Wed Jul 23 10:14:50 2008

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