1jgs
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(New page: 200px<br /><applet load="1jgs" size="450" color="white" frame="true" align="right" spinBox="true" caption="1jgs, resolution 2.3Å" /> '''Multiple Antibiotic R...)
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Revision as of 16:07, 20 November 2007
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Multiple Antibiotic Resistance Repressor, MarR
Overview
MarR is a regulator of multiple antibiotic resistance in Escherichia coli., It is the prototypical member of the MarR family of regulatory proteins, found in bacteria and archaea that play important roles in the development, of antibiotic resistance, a global health problem. Here we describe the, crystal structure of the MarR protein, determined at a resolution of 2.3, A. This is the first reported crystal structure of a member of this, newly-described protein family. The structure shows MarR as a dimer with, each subunit containing a winged-helix DNA binding motif.
About this Structure
1JGS is a Single protein structure of sequence from Escherichia coli with SAL as ligand. Full crystallographic information is available from OCA.
Reference
The crystal structure of MarR, a regulator of multiple antibiotic resistance, at 2.3 A resolution., Alekshun MN, Levy SB, Mealy TR, Seaton BA, Head JF, Nat Struct Biol. 2001 Aug;8(8):710-4. PMID:11473263
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