2vuk

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'''Unreleased structure'''
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{{Seed}}
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[[Image:2vuk.jpg|left|200px]]
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The entry 2vuk is ON HOLD until Paper Publication
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{{STRUCTURE_2vuk| PDB=2vuk | SCENE= }}
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Authors: Joerger, A.C., Boeckler, F.M., Fersht, A.R.
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===STRUCTURE OF THE P53 CORE DOMAIN MUTANT Y220C BOUND TO THE STABILIZING SMALL-MOLECULE DRUG PHIKAN083===
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Description: Structure of the p53 core domain mutant Y220C bound to the stabilizing small-molecule drug PhiKan083
 
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Jul 11 13:01:17 2008''
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{{ABSTRACT_PUBMED_17015838}}
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==About this Structure==
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2VUK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VUK OCA].
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==Reference==
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Structural basis for understanding oncogenic p53 mutations and designing rescue drugs., Joerger AC, Ang HC, Fersht AR, Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15056-61. Epub 2006 Oct 2. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17015838 17015838]
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[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Boeckler, F M.]]
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[[Category: Fersht, A R.]]
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[[Category: Joerger, A C.]]
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[[Category: Acetylation]]
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[[Category: Activator]]
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[[Category: Alternative splicing]]
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[[Category: Anti-oncogene]]
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[[Category: Apoptosis]]
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[[Category: Cancer]]
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[[Category: Cell cycle]]
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[[Category: Covalent protein-rna linkage]]
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[[Category: Cytoplasm]]
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[[Category: Disease mutation]]
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[[Category: Dna binding]]
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[[Category: Dna-binding]]
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[[Category: Dna-binding protein]]
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[[Category: Endoplasmic reticulum]]
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[[Category: Glycoprotein]]
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[[Category: Host-virus interaction]]
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[[Category: Li-fraumeni syndrome]]
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[[Category: Metal binding]]
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[[Category: Metal-binding]]
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[[Category: Methylation]]
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[[Category: Nuclear protein]]
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[[Category: Nucleus]]
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[[Category: P53 dna- binding domain]]
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[[Category: Phosphoprotein]]
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[[Category: Polymorphism]]
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[[Category: Protein stabilization]]
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[[Category: Second-site suppressor mutation]]
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[[Category: Small-molecule drug]]
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[[Category: Superstable mutant]]
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[[Category: Surface crevice]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: Tumor suppressor]]
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[[Category: Ubl conjugation]]
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[[Category: Virtual screening]]
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[[Category: Zinc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 23 11:42:46 2008''

Revision as of 08:42, 23 July 2008

Image:2vuk.jpg

Template:STRUCTURE 2vuk

STRUCTURE OF THE P53 CORE DOMAIN MUTANT Y220C BOUND TO THE STABILIZING SMALL-MOLECULE DRUG PHIKAN083

Template:ABSTRACT PUBMED 17015838

About this Structure

2VUK is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for understanding oncogenic p53 mutations and designing rescue drugs., Joerger AC, Ang HC, Fersht AR, Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15056-61. Epub 2006 Oct 2. PMID:17015838

Page seeded by OCA on Wed Jul 23 11:42:46 2008

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OCA

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