1jig
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(New page: 200px<br /><applet load="1jig" size="450" color="white" frame="true" align="right" spinBox="true" caption="1jig, resolution 1.46Å" /> '''Dlp-2 from Bacillus ...)
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Revision as of 16:10, 20 November 2007
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Dlp-2 from Bacillus anthracis
Overview
Bacillus anthracis is currently under intense investigation due to its, primary importance as a human pathogen. Particularly important is the, development of novel anti-anthrax vaccines, devoid of the current side, effects. A novel class of immunogenic bacterial proteins consists of, dodecamers homologous to the DNA-binding protein of Escherichia coli, (Dps). Two Dps homologous genes are present in the B. anthracis genome., The crystal structures of these two proteins (Dlp-1 and Dlp-2) have been, determined and are presented here. They are sphere-like proteins with an, internal cavity. We also show that they act as ferritins and are thus, involved in iron uptake and regulation, a fundamental function during, bacterial growth.
About this Structure
1JIG is a Single protein structure of sequence from Bacillus anthracis with FE as ligand. Full crystallographic information is available from OCA.
Reference
Structure of two iron-binding proteins from Bacillus anthracis., Papinutto E, Dundon WG, Pitulis N, Battistutta R, Montecucco C, Zanotti G, J Biol Chem. 2002 Apr 26;277(17):15093-8. Epub 2002 Feb 8. PMID:11836250
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