1jjo
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(New page: 200px<br /><applet load="1jjo" size="450" color="white" frame="true" align="right" spinBox="true" caption="1jjo, resolution 3.06Å" /> '''Crystal Structure of...)
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Revision as of 16:12, 20 November 2007
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Crystal Structure of Mouse Neuroserpin (Cleaved form)
Overview
The protease inhibitor neuroserpin regulates the development of the, nervous system and its plasticity in the adult. Neuroserpins carrying the, Ser53Pro or Ser56Arg mutation form polymers in neuronal cells. We describe, here the structure of wild-type neuroserpin in a cleaved form. The, structure provides a basis to understand the role of the mutations in the, polymerization process. We propose that these mutations could delay the, insertion of the reactive center loop into the central beta-sheet A, an, essential step in the inhibition and possibly in the polymerization of, neuroserpin.
About this Structure
1JJO is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.
Reference
Crystal structure of neuroserpin: a neuronal serpin involved in a conformational disease., Briand C, Kozlov SV, Sonderegger P, Grutter MG, FEBS Lett. 2001 Sep 7;505(1):18-22. PMID:11557034
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