1jjw
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(New page: 200px<br /><applet load="1jjw" size="450" color="white" frame="true" align="right" spinBox="true" caption="1jjw, resolution 1.90Å" /> '''Structure of Haemoph...)
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Revision as of 16:12, 20 November 2007
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Structure of Haemophilus influenzae HslV Protein at 1.9 A Resolution
Overview
The structure of the Haemophilus influenzae HslV protease of the HslUV, 'prokaryotic proteasome' has been solved by molecular replacement and, refined with data to 1.9 A resolution. The protease is a 'double donut' of, hexameric rings; two alternative sets of intermolecular interactions, between protomers in the rings result in 'quasi-equivalent' packing within, the assembly. Anomalous scattering data from crystals with potassium, present in the mother liquor reveal a K(+) ion bound with octahedral, coordination near the active-site Thr1 residue. The site also binds Na(+), ions and is likely to bind Mg(2+), suggesting that monovalent and divalent, metal ions may influence the catalytic activity of the protease.
About this Structure
1JJW is a Single protein structure of sequence from Haemophilus influenzae with K as ligand. Full crystallographic information is available from OCA.
Reference
Structure of Haemophilus influenzae HslV protein at 1.9 A resolution, revealing a cation-binding site near the catalytic site., Sousa MC, McKay DB, Acta Crystallogr D Biol Crystallogr. 2001 Dec;57(Pt 12):1950-4. Epub 2001, Nov 21. PMID:11717526
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