2fj7

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[[Image:2fj7.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_2fj7| PDB=2fj7 | SCENE= }}
{{STRUCTURE_2fj7| PDB=2fj7 | SCENE= }}
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'''Crystal structure of Nucleosome Core Particle Containing a Poly (dA.dT) Sequence Element'''
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===Crystal structure of Nucleosome Core Particle Containing a Poly (dA.dT) Sequence Element===
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==Overview==
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Poly(dA.dT) DNA sequence elements are thought to promote transcription by either excluding nucleosomes or by altering their structural or dynamic properties. Here, the stability and structure of a defined nucleosome core particle containing a 16 base-pair poly(dA.dT) element (A16 NCP) was investigated. The A16 NCP requires a significantly higher temperature for histone octamer sliding in vitro compared to comparable nucleosomes that do not contain a poly(dA.dT) element. Fluorescence resonance energy transfer showed that the interactions between the nucleosomal DNA ends and the histone octamer were destabilized in A16 NCP. The crystal structure of A16 NCP was determined to a resolution of 3.2 A. The overall structure was maintained except for local deviations in DNA conformation. These results are consistent with previous in vivo and in vitro observations that poly(dA.dT) elements cause only modest changes in DNA accessibility and modest increases in steady-state transcription levels.
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The line below this paragraph, {{ABSTRACT_PUBMED_16860337}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16860337 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16860337}}
==About this Structure==
==About this Structure==
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[[Category: Narrow minor groove]]
[[Category: Narrow minor groove]]
[[Category: Protein-dna complex]]
[[Category: Protein-dna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:57:39 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 23 13:38:40 2008''

Revision as of 10:38, 23 July 2008

Image:2fj7.png

Template:STRUCTURE 2fj7

Crystal structure of Nucleosome Core Particle Containing a Poly (dA.dT) Sequence Element

Template:ABSTRACT PUBMED 16860337

About this Structure

2FJ7 is a Protein complex structure of sequences from Xenopus laevis. Full crystallographic information is available from OCA.

Reference

Nucleosome core particles containing a poly(dA.dT) sequence element exhibit a locally distorted DNA structure., Bao Y, White CL, Luger K, J Mol Biol. 2006 Aug 25;361(4):617-24. Epub 2006 Jul 5. PMID:16860337

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