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2bjx

From Proteopedia

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[[Image:2bjx.jpg|left|200px]]
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{{STRUCTURE_2bjx| PDB=2bjx | SCENE= }}
{{STRUCTURE_2bjx| PDB=2bjx | SCENE= }}
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'''PROTEIN DISULFIDE ISOMERASE'''
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===PROTEIN DISULFIDE ISOMERASE===
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==Overview==
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Protein disulfide isomerase (PDI) is a multifunctional protein of the endoplasmic reticulum, which catalyzes the formation, breakage and rearrangement of disulfide bonds during protein folding. It consists of four domains designated a, b, b and a. Both a and a domains contains an active site with the sequence motif -Cys-Gly-His-Cys-involved directly in thiol-disulfide exchange reactions. As expected these domains have structures very similar to the ubiquitous redox protein thioredoxin. A low-resolution NMR structure of the b domain revealed that this domain adopts a fold similar to the PDI a domain and thioredoxin [Kemmink, J., Darby, N.J., Dijkstra, K., Nilges, M. and Creighton, T.E. (1997) Curr. Biol. 7, 239-245]. A refined ensemble of solution structures based on the input of 1865 structural restraints shows that the structure of PDI b is well defined throughout the complete protein except for about 10 residues at the C-terminus of the sequence. 15N relaxation data show that these residues are disordered and not part of this structural domain. Therefore the domain boundaries of PDI can now be fixed with reasonable precision. Structural comparison of the PDI b domain with thioredoxin and PDI a reveals several features important for thiol-disulfide exchange activity.
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(as it appears on PubMed at http://www.pubmed.gov), where 10383197 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10383197}}
==About this Structure==
==About this Structure==
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2BJX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BJX OCA].
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2BJX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BJX OCA].
==Reference==
==Reference==
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[[Category: Isomerase]]
[[Category: Isomerase]]
[[Category: Redox-active center]]
[[Category: Redox-active center]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:23:24 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 12:15:51 2008''

Revision as of 09:15, 27 July 2008

Image:2bjx.png

Template:STRUCTURE 2bjx

PROTEIN DISULFIDE ISOMERASE

Template:ABSTRACT PUBMED 10383197

About this Structure

2BJX is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

The structure in solution of the b domain of protein disulfide isomerase., Kemmink J, Dijkstra K, Mariani M, Scheek RM, Penka E, Nilges M, Darby NJ, J Biomol NMR. 1999 Apr;13(4):357-68. PMID:10383197

Page seeded by OCA on Sun Jul 27 12:15:51 2008

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