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1y4m

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[[Image:1y4m.gif|left|200px]]
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{{Seed}}
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[[Image:1y4m.png|left|200px]]
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{{STRUCTURE_1y4m| PDB=1y4m | SCENE= }}
{{STRUCTURE_1y4m| PDB=1y4m | SCENE= }}
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'''Crystal structure of human endogenous retrovirus HERV-FRD envelope protein (syncitin-2)'''
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===Crystal structure of human endogenous retrovirus HERV-FRD envelope protein (syncitin-2)===
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==Overview==
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HERV-FRD is a human endogenous retrovirus that entered the human genome 40 million years ago. Its envelope gene, syncytin-2, was diverted by an ancestral host most probably because of its fusogenic property, for a role in placenta morphogenesis. It was maintained in a functional state in all primate branches as a bona fide cellular gene, submitted to a very low mutation rate as compared to infectious retrovirus genomes. The structure of the syncytin-2 protein thus provides a good insight into that of the oldest mammalian retroviral envelope. Here, we report the crystal structure of a central fragment of its "fossil" ectodomain, allowing a remarkable superposition with the structures of the corresponding domains of present-day infectious retroviruses, in spite of a more than 60% divergent sequence. These results suggest the existence of a unique structural solution selected by these proteins for their fusogenic function.
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The line below this paragraph, {{ABSTRACT_PUBMED_16140326}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16140326 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16140326}}
==About this Structure==
==About this Structure==
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[[Category: Endogenous retrovirus]]
[[Category: Endogenous retrovirus]]
[[Category: Membrane fusion]]
[[Category: Membrane fusion]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:52:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 12:17:37 2008''

Revision as of 09:17, 27 July 2008

Image:1y4m.png

Template:STRUCTURE 1y4m

Crystal structure of human endogenous retrovirus HERV-FRD envelope protein (syncitin-2)

Template:ABSTRACT PUBMED 16140326

About this Structure

1Y4M is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of a pivotal domain of human syncytin-2, a 40 million years old endogenous retrovirus fusogenic envelope gene captured by primates., Renard M, Varela PF, Letzelter C, Duquerroy S, Rey FA, Heidmann T, J Mol Biol. 2005 Oct 7;352(5):1029-34. PMID:16140326

Page seeded by OCA on Sun Jul 27 12:17:37 2008

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