1w9d

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[[Image:1w9d.gif|left|200px]]
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{{Seed}}
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[[Image:1w9d.png|left|200px]]
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{{STRUCTURE_1w9d| PDB=1w9d | SCENE= }}
{{STRUCTURE_1w9d| PDB=1w9d | SCENE= }}
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'''S. ALBA MYROSINASE IN COMPLEX WITH S-ETHYL PHENYLACETOTHIOHYDROXIMATE-O-SULFATE'''
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===S. ALBA MYROSINASE IN COMPLEX WITH S-ETHYL PHENYLACETOTHIOHYDROXIMATE-O-SULFATE===
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==Overview==
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Myrosinase, a thioglucoside glucohydrolase, is the only enzyme able to hydrolyse glucosinolates, a unique family of molecules bearing an anomeric O-sulfated thiohydroximate function. Non-hydrolysable myrosinase inhibitors have been devised and studied for their biological interaction. Diverse modifications of the O-sulfate moiety did not result in a significant inhibitory effect, whereas replacing the D-glucopyrano residue by its carba-analogue allowed inhibition to take place. X-Ray experiments carried out after soaking allowed for the first time inclusion of a non-hydrolysable inhibitor inside the enzymatic pocket. Structural tuning of the aglycon part in its pocket is being used as a guide for the development of simplified and more potent inhibitors.
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The line below this paragraph, {{ABSTRACT_PUBMED_15889170}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15889170 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15889170}}
==About this Structure==
==About this Structure==
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[[Category: Thioglycosidase]]
[[Category: Thioglycosidase]]
[[Category: Thiohydroximate]]
[[Category: Thiohydroximate]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:20:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 12:18:04 2008''

Revision as of 09:18, 27 July 2008

Image:1w9d.png

Template:STRUCTURE 1w9d

S. ALBA MYROSINASE IN COMPLEX WITH S-ETHYL PHENYLACETOTHIOHYDROXIMATE-O-SULFATE

Template:ABSTRACT PUBMED 15889170

About this Structure

1W9D is a Single protein structure of sequence from Sinapis alba. Full crystallographic information is available from OCA.

Reference

The glucosinolate-myrosinase system. New insights into enzyme-substrate interactions by use of simplified inhibitors., Bourderioux A, Lefoix M, Gueyrard D, Tatibouet A, Cottaz S, Arzt S, Burmeister WP, Rollin P, Org Biomol Chem. 2005 May 21;3(10):1872-9. Epub 2005 Apr 14. PMID:15889170

Page seeded by OCA on Sun Jul 27 12:18:04 2008

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