3bsn

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{{STRUCTURE_3bsn| PDB=3bsn | SCENE= }}
{{STRUCTURE_3bsn| PDB=3bsn | SCENE= }}
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'''Norwalk Virus polymerase bound to 5-nitrocytidine triphosphate and primer-template RNA'''
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===Norwalk Virus polymerase bound to 5-nitrocytidine triphosphate and primer-template RNA===
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==Overview==
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Crystal structures of Norwalk virus polymerase bound to an RNA primer-template duplex and either the natural substrate CTP or the inhibitor 5-nitrocytidine triphosphate have been determined to 1.8A resolution. These structures reveal a closed conformation of the polymerase that differs significantly from previously determined open structures of calicivirus and picornavirus polymerases. These closed complexes are trapped immediately prior to the nucleotidyl transfer reaction, with the triphosphate group of the nucleotide bound to two manganese ions at the active site, poised for reaction to the 3'-hydroxyl group of the RNA primer. The positioning of the 5-nitrocytidine triphosphate nitro group between the alpha-phosphate and the 3'-hydroxyl group of the primer suggests a novel, general approach for the design of antiviral compounds mimicking natural nucleosides and nucleotides.
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(as it appears on PubMed at http://www.pubmed.gov), where 18184655 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18184655}}
==About this Structure==
==About this Structure==
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[[Category: Transferase/rna complex]]
[[Category: Transferase/rna complex]]
[[Category: Viral replication]]
[[Category: Viral replication]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 21:03:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 12:18:03 2008''

Revision as of 09:18, 27 July 2008

Image:3bsn.png

Template:STRUCTURE 3bsn

Norwalk Virus polymerase bound to 5-nitrocytidine triphosphate and primer-template RNA

Template:ABSTRACT PUBMED 18184655

About this Structure

3BSN is a Protein complex structure of sequences from Norwalk virus. Full crystallographic information is available from OCA.

Reference

Structural insights into mechanisms of catalysis and inhibition in norwalk virus polymerase., Zamyatkin DF, Parra F, Alonso JM, Harki DA, Peterson BR, Grochulski P, Ng KK, J Biol Chem. 2008 Mar 21;283(12):7705-12. Epub 2008 Jan 9. PMID:18184655

Page seeded by OCA on Sun Jul 27 12:18:03 2008

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