1p5m

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{{STRUCTURE_1p5m| PDB=1p5m | SCENE= }}
{{STRUCTURE_1p5m| PDB=1p5m | SCENE= }}
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'''Solution Structure of HCV IRES Domain IIa'''
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===Solution Structure of HCV IRES Domain IIa===
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==Overview==
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Complex RNA structures regulate many biological processes, but are often too large for structure determination by NMR methods. The 5' untranslated region (5' UTR) of the hepatitis C viral (HCV) RNA genome contains an internal ribosome entry site (IRES) that binds to 40S ribosomal subunits with high affinity and specificity to control translation. Domain II of the HCV IRES forms a 25-kDa folded subdomain that may alter ribosome conformation. We report here the structure of domain II as determined using an NMR approach that combines short- and long-range structural data. Domain II adopts a distorted L-shape structure, and its overall shape in the free form is markedly similar to its 40S subunit-bound form; this suggests how domain II may modulate 40S subunit conformation. The results show how NMR can be used for structural analysis of large biological RNAs.
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The line below this paragraph, {{ABSTRACT_PUBMED_14578934}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 14578934 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14578934}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P5M OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P5M OCA].
==Reference==
==Reference==
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[[Category: Ribonucleic acid]]
[[Category: Ribonucleic acid]]
[[Category: Trna]]
[[Category: Trna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:42:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 12:20:42 2008''

Revision as of 09:20, 27 July 2008

Image:1p5m.png

Template:STRUCTURE 1p5m

Solution Structure of HCV IRES Domain IIa

Template:ABSTRACT PUBMED 14578934

About this Structure

Full experimental information is available from OCA.

Reference

Structure of HCV IRES domain II determined by NMR., Lukavsky PJ, Kim I, Otto GA, Puglisi JD, Nat Struct Biol. 2003 Dec;10(12):1033-8. Epub 2003 Oct 26. PMID:14578934

Page seeded by OCA on Sun Jul 27 12:20:42 2008

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