1y08

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{{STRUCTURE_1y08| PDB=1y08 | SCENE= }}
{{STRUCTURE_1y08| PDB=1y08 | SCENE= }}
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'''Structure of the Streptococcal Endopeptidase IdeS, a Novel Cysteine Proteinase with Strict Specificity for IgG'''
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===Structure of the Streptococcal Endopeptidase IdeS, a Novel Cysteine Proteinase with Strict Specificity for IgG===
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==Overview==
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Pathogenic bacteria have developed complex and diverse virulence mechanisms that weaken or disable the host immune defense system. IdeS (IgG-degrading enzyme of Streptococcus pyogenes) is a secreted cysteine endopeptidase from the human pathogen S. pyogenes with an extraordinarily high degree of substrate specificity, catalyzing a single proteolytic cleavage at the lower hinge of human IgG. This proteolytic degradation promotes inhibition of opsonophagocytosis and interferes with the killing of group A Streptococcus. We have determined the crystal structure of the catalytically inactive mutant IdeS-C94S by x-ray crystallography at 1.9-A resolution. Despite negligible sequence homology to known proteinases, the core of the structure resembles the canonical papain fold although with major insertions and a distinct substrate-binding site. Therefore IdeS belongs to a unique family within the CA clan of cysteine proteinases. Based on analogy with inhibitor complexes of papain-like proteinases, we propose a model for substrate binding by IdeS.
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(as it appears on PubMed at http://www.pubmed.gov), where 15574492 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15574492}}
==About this Structure==
==About this Structure==
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[[Category: Cysteine proteinase]]
[[Category: Cysteine proteinase]]
[[Category: Papain-like fold with major insertion]]
[[Category: Papain-like fold with major insertion]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:43:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 12:20:49 2008''

Revision as of 09:20, 27 July 2008

Image:1y08.png

Template:STRUCTURE 1y08

Structure of the Streptococcal Endopeptidase IdeS, a Novel Cysteine Proteinase with Strict Specificity for IgG

Template:ABSTRACT PUBMED 15574492

About this Structure

1Y08 is a Single protein structure of sequence from Streptococcus pyogenes. Full crystallographic information is available from OCA.

Reference

Structure of the streptococcal endopeptidase IdeS, a cysteine proteinase with strict specificity for IgG., Wenig K, Chatwell L, von Pawel-Rammingen U, Bjorck L, Huber R, Sondermann P, Proc Natl Acad Sci U S A. 2004 Dec 14;101(50):17371-6. Epub 2004 Dec 1. PMID:15574492

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