1n47

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{{STRUCTURE_1n47| PDB=1n47 | SCENE= }}
{{STRUCTURE_1n47| PDB=1n47 | SCENE= }}
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'''Isolectin B4 from Vicia villosa in complex with the Tn antigen'''
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===Isolectin B4 from Vicia villosa in complex with the Tn antigen===
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==Overview==
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The structure of the tetrameric Vicia villosa isolectin B4 (VVLB4) in complex with a cancer antigen, the Tn glycopeptide (GalNAc-O-Ser), was determined at 2.7 A resolution. The N-acetylgalactoside moiety of the ligand binds to the primary combining site of VVLB4 in a similar way as observed for other Gal/GalNAc-specific plant lectins. The amino acid moiety of the Tn antigen is largely exposed to the solvent and makes few contacts with the protein. The structure of the complex provides a framework to understand the differences in the strength of VVLB4 binding to different sugars and emphasizes the role of a single protein residue, Tyr127, as a structural determinant of Tn-binding specificity.
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(as it appears on PubMed at http://www.pubmed.gov), where 12586347 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12586347}}
==About this Structure==
==About this Structure==
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[[Category: Glycoprotein tn-binding protein]]
[[Category: Glycoprotein tn-binding protein]]
[[Category: Vicia villosa lectin]]
[[Category: Vicia villosa lectin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:04:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 12:22:40 2008''

Revision as of 09:22, 27 July 2008

Image:1n47.png

Template:STRUCTURE 1n47

Isolectin B4 from Vicia villosa in complex with the Tn antigen

Template:ABSTRACT PUBMED 12586347

About this Structure

Full crystallographic information is available from OCA.

Reference

The crystal structure of a plant lectin in complex with the Tn antigen., Babino A, Tello D, Rojas A, Bay S, Osinaga E, Alzari PM, FEBS Lett. 2003 Feb 11;536(1-3):106-10. PMID:12586347

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