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2h0d

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{{STRUCTURE_2h0d| PDB=2h0d | SCENE= }}
{{STRUCTURE_2h0d| PDB=2h0d | SCENE= }}
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'''Structure of a Bmi-1-Ring1B Polycomb group ubiquitin ligase complex'''
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===Structure of a Bmi-1-Ring1B Polycomb group ubiquitin ligase complex===
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==Overview==
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Polycomb group proteins Bmi-1 and Ring1B are core subunits of the PRC1 complex, which plays important roles in the regulation of Hox gene expression, X-chromosome inactivation, tumorigenesis, and stem cell self-renewal. The RING finger protein Ring1B is an E3 ligase that participates in the ubiquitination of lysine 119 of histone H2A, and the binding of Bmi-1 stimulates the E3 ligase activity. We have mapped the regions of Bmi-1 and Ring1B required for efficient ubiquitin transfer and determined a 2.5-A structure of the Bmi-1-Ring1B core domain complex. The structure reveals that Ring1B "hugs" Bmi-1 through extensive RING domain contacts and its N-terminal tail wraps around Bmi-1. The two regions of interaction have a synergistic effect on the E3 ligase activity. Our analyses suggest a model where the Bmi-1-Ring1B complex stabilizes the interaction between the E2 enzyme and the nucleosomal substrate to allow efficient ubiquitin transfer.
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The line below this paragraph, {{ABSTRACT_PUBMED_16714294}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16714294 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16714294}}
==About this Structure==
==About this Structure==
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[[Category: Ubiquitin ligase]]
[[Category: Ubiquitin ligase]]
[[Category: Wpigenetic]]
[[Category: Wpigenetic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:43:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 12:23:06 2008''

Revision as of 09:23, 27 July 2008

Image:2h0d.png

Template:STRUCTURE 2h0d

Structure of a Bmi-1-Ring1B Polycomb group ubiquitin ligase complex

Template:ABSTRACT PUBMED 16714294

About this Structure

2H0D is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of a Bmi-1-Ring1B polycomb group ubiquitin ligase complex., Li Z, Cao R, Wang M, Myers MP, Zhang Y, Xu RM, J Biol Chem. 2006 Jul 21;281(29):20643-9. Epub 2006 May 18. PMID:16714294

Page seeded by OCA on Sun Jul 27 12:23:06 2008

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