1nd3

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{{STRUCTURE_1nd3| PDB=1nd3 | SCENE= }}
{{STRUCTURE_1nd3| PDB=1nd3 | SCENE= }}
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'''The structure of HRV16, when complexed with pleconaril, an antiviral compound'''
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===The structure of HRV16, when complexed with pleconaril, an antiviral compound===
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==Overview==
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Pleconaril is a broad-spectrum antirhinovirus and antienterovirus compound that binds into a hydrophobic pocket within viral protein 1, stabilizing the capsid and resulting in the inhibition of cell attachment and RNA uncoating. When crystals of human rhinovirus 16 (HRV16) and HRV14 are incubated with pleconaril, drug occupancy in the binding pocket is lower than when pleconaril is introduced during assembly prior to crystallization. This effect is far more marked in HRV16 than in HRV14 and is more marked with pleconaril than with other compounds. These observations are consistent with virus yield inhibition studies and radiolabeled drug binding studies showing that the antiviral effect of pleconaril against HRV16 is greater on the infectivity of progeny virions than the parent input viruses. These data suggest that drug integration into the binding pocket during assembly, or at some other late stage in virus replication, may contribute to the antiviral activity of capsid binding compounds.
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{{ABSTRACT_PUBMED_15452226}}
==About this Structure==
==About this Structure==
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[[Category: Pleconaril]]
[[Category: Pleconaril]]
[[Category: Rhinovirus]]
[[Category: Rhinovirus]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:23:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 12:23:20 2008''

Revision as of 09:23, 27 July 2008

Image:1nd3.png

Template:STRUCTURE 1nd3

The structure of HRV16, when complexed with pleconaril, an antiviral compound

Template:ABSTRACT PUBMED 15452226

About this Structure

1ND3 is a Protein complex structure of sequences from Human rhinovirus 16. Full crystallographic information is available from OCA.

Reference

Structural and virological studies of the stages of virus replication that are affected by antirhinovirus compounds., Zhang Y, Simpson AA, Ledford RM, Bator CM, Chakravarty S, Skochko GA, Demenczuk TM, Watanyar A, Pevear DC, Rossmann MG, J Virol. 2004 Oct;78(20):11061-9. PMID:15452226

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