1zhb

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{{STRUCTURE_1zhb| PDB=1zhb | SCENE= }}
{{STRUCTURE_1zhb| PDB=1zhb | SCENE= }}
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'''Crystal Structure Of The Murine Class I Major Histocompatibility Complex Of H-2Db, B2-Microglobulin, and a 9-Residue Peptide Derived from rat dopamine beta-monooxigenase'''
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===Crystal Structure Of The Murine Class I Major Histocompatibility Complex Of H-2Db, B2-Microglobulin, and a 9-Residue Peptide Derived from rat dopamine beta-monooxigenase===
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==Overview==
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Molecular mimicry of self-epitopes by viral antigens is one possible pathogenic mechanism underlying induction of autoimmunity. A self-epitope, mDBM, derived from mouse dopamine beta-mono-oxygenase (KALYDYAPI) sharing 44% sequence identity with the lymphocytic choriomeningitis virus-derived immunodominant epitope gp33 (KAVYNFATC/M), has previously been identified as a cross-reactive self-ligand, presentation of which results in autoimmunity. A rat peptide homologue, rDBM (KALYNYAPI, 56% identity to gp33), which displayed similar properties to mDBM, has also been identified. We herein report the crystal structure of H-2Db.rDBM and a comparison with the crystal structures of the cross-reactive H-2Db.gp33 and non-cross-reactive H-2Db.gp33 (V3L) escape variant (KALYNFATM, 88% identity to gp33). Despite the large sequence disparity, rDBM and gp33 peptides are presented in nearly identical manners by H-2Db, with a striking juxtaposition of the central sections of both peptides from residues p3 to p7. The structural similarity provides H-2Db in complex with either a virus-derived or a dopamine beta-mono-oxygenase-derived peptide with a shared antigenic identity that conserves the positioning of the heavy chain and peptide residues that interact with the T cell receptor (TCR). This stands in contrast to the structure of H-2Db.gp33 (V3L), in which a single conserved mutation, also present in rDBM, induces large movements of both the peptide backbone and the side chains that interact with the TCR. The TCR-interacting surfaces of the H-2Db.rDBM and H-2Db.gp33 major histocompatibility complexes are very similar with regard to shape, topology, and charge distribution, providing a structural basis for CD8 T cell activation by molecular mimicry and potential subsequent development of autoreactivity.
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{{ABSTRACT_PUBMED_15845547}}
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
A structural basis for CD8+ T cell-dependent recognition of non-homologous peptide ligands: implications for molecular mimicry in autoreactivity., Sandalova T, Michaelsson J, Harris RA, Odeberg J, Schneider G, Karre K, Achour A, J Biol Chem. 2005 Jul 22;280(29):27069-75. Epub 2005 Apr 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15845547 15845547]
A structural basis for CD8+ T cell-dependent recognition of non-homologous peptide ligands: implications for molecular mimicry in autoreactivity., Sandalova T, Michaelsson J, Harris RA, Odeberg J, Schneider G, Karre K, Achour A, J Biol Chem. 2005 Jul 22;280(29):27069-75. Epub 2005 Apr 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15845547 15845547]
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A structural basis for LCMV immune evasion: subversion of H-2D(b) and H-2K(b) presentation of gp33 revealed by comparative crystal structure.Analyses., Achour A, Michaelsson J, Harris RA, Odeberg J, Grufman P, Sandberg JK, Levitsky V, Karre K, Sandalova T, Schneider G, Immunity. 2002 Dec;17(6):757-68. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12479822 12479822]
[[Category: Dopamine beta-monooxygenase]]
[[Category: Dopamine beta-monooxygenase]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Self-ligand]]
[[Category: Self-ligand]]
[[Category: Tcr-crossreactivity]]
[[Category: Tcr-crossreactivity]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:37:25 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 12:24:24 2008''

Revision as of 09:24, 27 July 2008

Image:1zhb.png

Template:STRUCTURE 1zhb

Crystal Structure Of The Murine Class I Major Histocompatibility Complex Of H-2Db, B2-Microglobulin, and a 9-Residue Peptide Derived from rat dopamine beta-monooxigenase

Template:ABSTRACT PUBMED 15845547

About this Structure

1ZHB is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

A structural basis for CD8+ T cell-dependent recognition of non-homologous peptide ligands: implications for molecular mimicry in autoreactivity., Sandalova T, Michaelsson J, Harris RA, Odeberg J, Schneider G, Karre K, Achour A, J Biol Chem. 2005 Jul 22;280(29):27069-75. Epub 2005 Apr 21. PMID:15845547

A structural basis for LCMV immune evasion: subversion of H-2D(b) and H-2K(b) presentation of gp33 revealed by comparative crystal structure.Analyses., Achour A, Michaelsson J, Harris RA, Odeberg J, Grufman P, Sandberg JK, Levitsky V, Karre K, Sandalova T, Schneider G, Immunity. 2002 Dec;17(6):757-68. PMID:12479822

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