2b4s

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{{STRUCTURE_2b4s| PDB=2b4s | SCENE= }}
{{STRUCTURE_2b4s| PDB=2b4s | SCENE= }}
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'''Crystal structure of a complex between PTP1B and the insulin receptor tyrosine kinase'''
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===Crystal structure of a complex between PTP1B and the insulin receptor tyrosine kinase===
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==Overview==
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Protein tyrosine phosphatase 1B (PTP1B) is a highly specific negative regulator of insulin receptor signaling in vivo. The determinants of PTP1B specificity for the insulin receptor versus other receptor tyrosine kinases are largely unknown. Here, we report a crystal structure at 2.3 A resolution of the catalytic domain of PTP1B (trapping mutant) in complex with the phosphorylated tyrosine kinase domain of the insulin receptor (IRK). The crystallographic asymmetric unit contains two PTP1B-IRK complexes that interact through an IRK dimer interface. Rather than binding to a phosphotyrosine in the IRK activation loop, PTP1B binds instead to the opposite side of the kinase domain, with the phosphorylated activation loops sequestered within the IRK dimer. The crystal structure provides evidence for a noncatalytic mode of interaction between PTP1B and IRK, which could be important for the selective recruitment of PTP1B to the insulin receptor.
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{{ABSTRACT_PUBMED_16271887}}
==Disease==
==Disease==
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[[Category: Phosphorylation]]
[[Category: Phosphorylation]]
[[Category: Tyrosine protein kinase]]
[[Category: Tyrosine protein kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:51:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 12:24:37 2008''

Revision as of 09:24, 27 July 2008

Image:2b4s.png

Template:STRUCTURE 2b4s

Contents

Crystal structure of a complex between PTP1B and the insulin receptor tyrosine kinase

Template:ABSTRACT PUBMED 16271887

Disease

Known disease associated with this structure: Diabetes mellitus, insulin-resistant, with acanthosis nigricans OMIM:[147670], Hyperinsulinemic hypoglycemia, familial, 5 OMIM:[147670], Leprechaunism OMIM:[147670], Rabson-Mendenhall syndrome OMIM:[147670]

About this Structure

2B4S is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of a complex between protein tyrosine phosphatase 1B and the insulin receptor tyrosine kinase., Li S, Depetris RS, Barford D, Chernoff J, Hubbard SR, Structure. 2005 Nov;13(11):1643-51. PMID:16271887

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