1qmw

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[[Image:1qmw.jpg|left|200px]]
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{{STRUCTURE_1qmw| PDB=1qmw | SCENE= }}
{{STRUCTURE_1qmw| PDB=1qmw | SCENE= }}
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'''SOLUTION STRUCTURE OF ALPHA-CONOTOXIN SI'''
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===SOLUTION STRUCTURE OF ALPHA-CONOTOXIN SI===
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==Overview==
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The nuclear magnetic resonance solution structure of alpha-conotoxin SI has been determined at pH 4.2. The 36 lowest energy structures show that alpha-conotoxin SI exists in a single major solution conformation and is stabilized by six hydrogen bonds. Comparisons are made between the SI solution structure and the solution and crystal structures of alpha-conotoxin GI. Surprisingly, a high degree of similarity between the backbone conformations of the GI crystal and the SI solution structures is seen in the region of lowest sequence homology, namely residues Gly-8 to Ser-12. This similarity is more surprising when considering that in SI a proline replaces the Arg-9 found in GI. The correspondence in conformation in this region provides the definitive evidence that it is the loss of the arginine basic charge at residue 9 which determines the differences in toxicity between GI and SI, rather than any changes in conformation induced by the cyclic proline residue.
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The line below this paragraph, {{ABSTRACT_PUBMED_10913630}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10913630 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10913630}}
==About this Structure==
==About this Structure==
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1QMW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Conus_striatus Conus striatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QMW OCA].
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1QMW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Conus_striatus Conus striatus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QMW OCA].
==Reference==
==Reference==
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[[Category: Toxin]]
[[Category: Toxin]]
[[Category: Venom]]
[[Category: Venom]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:27:57 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 12:25:54 2008''

Revision as of 09:26, 27 July 2008

Image:1qmw.png

Template:STRUCTURE 1qmw

SOLUTION STRUCTURE OF ALPHA-CONOTOXIN SI

Template:ABSTRACT PUBMED 10913630

About this Structure

1QMW is a Single protein structure of sequence from Conus striatus. Full experimental information is available from OCA.

Reference

Solution structure of alpha-conotoxin SI., Benie AJ, Whitford D, Hargittai B, Barany G, Janes RW, FEBS Lett. 2000 Jul 7;476(3):287-95. PMID:10913630

Page seeded by OCA on Sun Jul 27 12:25:54 2008

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