1njg

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[[Image:1njg.gif|left|200px]]
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{{STRUCTURE_1njg| PDB=1njg | SCENE= }}
{{STRUCTURE_1njg| PDB=1njg | SCENE= }}
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'''Nucleotide-free form of an Isolated E. coli Clamp Loader Gamma Subunit'''
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===Nucleotide-free form of an Isolated E. coli Clamp Loader Gamma Subunit===
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==Overview==
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Sliding clamps are loaded onto DNA by ATP-driven clamp loader complexes. The structure of the E. coli clamp loader in a nucleotide-free state has been determined previously. We now report crystal structures of a truncated form of the isolated gamma-ATPase subunit, gamma(1-243), of the E. coli clamp loader, in nucleotide-free and bound forms. The gamma subunit adopts a defined conformation when empty, in which the nucleotide binding site is blocked. The binding of either ATPgammaS or ADP, which are shown to bind with equal affinity to gamma(1-243), induces a change in the relative orientation of the two domains such that nucleotides can be accommodated. This change would break one of the gamma:gamma interfaces seen in the empty clamp loader complex, and may represent one step in the activation process.
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(as it appears on PubMed at http://www.pubmed.gov), where 12623013 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12623013}}
==About this Structure==
==About this Structure==
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:36:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 12:29:04 2008''

Revision as of 09:29, 27 July 2008

Image:1njg.png

Template:STRUCTURE 1njg

Nucleotide-free form of an Isolated E. coli Clamp Loader Gamma Subunit

Template:ABSTRACT PUBMED 12623013

About this Structure

1NJG is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Nucleotide-induced conformational changes in an isolated Escherichia coli DNA polymerase III clamp loader subunit., Podobnik M, Weitze TF, O'Donnell M, Kuriyan J, Structure. 2003 Mar;11(3):253-63. PMID:12623013

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