2ki5

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2ki5.gif|left|200px]]
+
{{Seed}}
 +
[[Image:2ki5.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2ki5| PDB=2ki5 | SCENE= }}
{{STRUCTURE_2ki5| PDB=2ki5 | SCENE= }}
-
'''HERPES SIMPLEX TYPE-1 THYMIDINE KINASE IN COMPLEX WITH THE DRUG ACICLOVIR AT 1.9A RESOLUTION'''
+
===HERPES SIMPLEX TYPE-1 THYMIDINE KINASE IN COMPLEX WITH THE DRUG ACICLOVIR AT 1.9A RESOLUTION===
-
==Overview==
+
<!--
-
Treatment of herpes infections with nucleoside analogues requires as an initial step the activation of the compounds by thymidine kinase. As an aid to developing more effective chemotherapy, both for treatment of recurrent herpes infection and in gene therapy systems where thymidine kinase is expressed, two high-resolution X-ray structures of thymidine kinase have been compared: one with the relatively poor substrate aciclovir (Zovirax), the other with a synthetic inhibitor having an N2-substituted guanine. Both compounds have similar binding modes in spite of their size difference and apparently distinct ligand properties.
+
The line below this paragraph, {{ABSTRACT_PUBMED_9989588}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 9989588 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_9989588}}
==About this Structure==
==About this Structure==
Line 35: Line 39:
[[Category: Herpesviridae]]
[[Category: Herpesviridae]]
[[Category: Viridae]]
[[Category: Viridae]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:29:06 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 12:29:16 2008''

Revision as of 09:29, 27 July 2008

Image:2ki5.png

Template:STRUCTURE 2ki5

HERPES SIMPLEX TYPE-1 THYMIDINE KINASE IN COMPLEX WITH THE DRUG ACICLOVIR AT 1.9A RESOLUTION

Template:ABSTRACT PUBMED 9989588

About this Structure

2KI5 is a Single protein structure of sequence from Human herpesvirus 1. This structure supersedes the now removed PDB entry 1ki5. Full crystallographic information is available from OCA.

Reference

Structure to 1.9 A resolution of a complex with herpes simplex virus type-1 thymidine kinase of a novel, non-substrate inhibitor: X-ray crystallographic comparison with binding of aciclovir., Bennett MS, Wien F, Champness JN, Batuwangala T, Rutherford T, Summers WC, Sun H, Wright G, Sanderson MR, FEBS Lett. 1999 Jan 25;443(2):121-5. PMID:9989588

Page seeded by OCA on Sun Jul 27 12:29:16 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2ki5"
Personal tools