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2uym

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[[Image:2uym.gif|left|200px]]
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[[Image:2uym.png|left|200px]]
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{{STRUCTURE_2uym| PDB=2uym | SCENE= }}
{{STRUCTURE_2uym| PDB=2uym | SCENE= }}
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'''CRYSTAL STRUCTURE OF KSP IN COMPLEX WITH ADP AND THIOPHENE CONTAINING INHIBITOR 37'''
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===CRYSTAL STRUCTURE OF KSP IN COMPLEX WITH ADP AND THIOPHENE CONTAINING INHIBITOR 37===
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==Overview==
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We have identified and synthesized a series of thiophene containing inhibitors of kinesin spindle protein. SAR studies led to the synthesis of 33, which was co-crystallized with KSP and determined to bind to an allosteric pocket previously described for other known KSP inhibitors.
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(as it appears on PubMed at http://www.pubmed.gov), where 17498954 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17498954}}
==About this Structure==
==About this Structure==
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[[Category: Phosphorylation]]
[[Category: Phosphorylation]]
[[Category: Thiophene]]
[[Category: Thiophene]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 17:49:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 12:31:07 2008''

Revision as of 09:31, 27 July 2008

Image:2uym.png

Template:STRUCTURE 2uym

CRYSTAL STRUCTURE OF KSP IN COMPLEX WITH ADP AND THIOPHENE CONTAINING INHIBITOR 37

Template:ABSTRACT PUBMED 17498954

About this Structure

2UYM is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Synthesis and SAR of thiophene containing kinesin spindle protein (KSP) inhibitors., Pinkerton AB, Lee TT, Hoffman TZ, Wang Y, Kahraman M, Cook TG, Severance D, Gahman TC, Noble SA, Shiau AK, Davis RL, Bioorg Med Chem Lett. 2007 Jul 1;17(13):3562-9. Epub 2007 Apr 29. PMID:17498954

Page seeded by OCA on Sun Jul 27 12:31:07 2008

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