2alc

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{{STRUCTURE_2alc| PDB=2alc | SCENE= }}
{{STRUCTURE_2alc| PDB=2alc | SCENE= }}
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'''ETHANOL REGULON TRANSCRIPTIONAL ACTIVATOR DNA-BINDING DOMAIN FROM ASPERGILLUS NIDULANS'''
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===ETHANOL REGULON TRANSCRIPTIONAL ACTIVATOR DNA-BINDING DOMAIN FROM ASPERGILLUS NIDULANS===
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==Overview==
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The three-dimensional structure of the DNA-binding domain (residues 1-60) of the ethanol regulon transcription factor AlcR from Aspergillus nidulans has been solved by NMR. This domain belongs to the zinc binuclear cluster class. Although the core of the protein is similar to previously characterized structures, consisting of two helices organized around a Zn(2)Cys(6 )motif, the present structure presents important variations, among them the presence of two supplementary helices. This structure gives new insight into the understanding of the AlcR specificities in DNA binding such as longer consensus half-sites, in vitro monomeric binding but in vivo multiple repeat transcriptional activation, either in direct or inverse orientations. The presence of additional contacts of the protein with its DNA target can be predicted from a model proposed for the interaction with the consensus DNA target. The clustering of accessible negative charges on helix 2 delineates a possible interaction site for other determinants of the transcriptional machinery, responsible for the fine tuning of the selection of the AlcR cognate sites.
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{{ABSTRACT_PUBMED_10656785}}
==About this Structure==
==About this Structure==
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2ALC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Emericella_nidulans Emericella nidulans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ALC OCA].
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2ALC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Emericella_nidulans Emericella nidulans]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ALC OCA].
==Reference==
==Reference==
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[[Category: Transcriptional activator]]
[[Category: Transcriptional activator]]
[[Category: Zinc binuclear cluster]]
[[Category: Zinc binuclear cluster]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:11:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 12:31:55 2008''

Revision as of 09:31, 27 July 2008

Image:2alc.png

Template:STRUCTURE 2alc

ETHANOL REGULON TRANSCRIPTIONAL ACTIVATOR DNA-BINDING DOMAIN FROM ASPERGILLUS NIDULANS

Template:ABSTRACT PUBMED 10656785

About this Structure

2ALC is a Single protein structure of sequence from Emericella nidulans. Full experimental information is available from OCA.

Reference

NMR solution structure of AlcR (1-60) provides insight in the unusual DNA binding properties of this zinc binuclear cluster protein., Cerdan R, Cahuzac B, Felenbok B, Guittet E, J Mol Biol. 2000 Jan 28;295(4):729-36. PMID:10656785

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