This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2ziu

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px <!-- The line below this paragraph, containing "STRUCTURE_2ziu", creates the "Structure Box" on the page. You may change the PDB parameter (which sets the PD...)
Line 1: Line 1:
-
[[Image:2ziu.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:2ziu.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2ziu| PDB=2ziu | SCENE= }}
{{STRUCTURE_2ziu| PDB=2ziu | SCENE= }}
-
'''Crystal structure of the Mus81-Eme1 complex'''
+
===Crystal structure of the Mus81-Eme1 complex===
-
==Overview==
+
<!--
-
The Mus81-Eme1 complex is a structure-specific endonuclease that plays an important role in rescuing stalled replication forks and resolving the meiotic recombination intermediates in eukaryotes. We have determined the crystal structure of the Mus81-Eme1 complex. Both Mus81 and Eme1 consist of a central nuclease domain, two repeats of the helix-hairpin-helix (HhH) motif at their C-terminal region, and a linker helix. While each domain structure resembles archaeal XPF homologs, the overall structure is significantly different from those due to the structure of a linker helix. We show that a flexible intradomain linker that formed with 36 residues in the nuclease domain of Eme1 is essential for the recognition of DNA. We identified several basic residues lining the outer surface of the active site cleft of Mus81 that are involved in the interaction with a flexible arm of a nicked Holliday junction (HJ). These interactions might contribute to the optimal positioning of the opposite junction across the nick into the catalytic site, which provided the basis for the "nick and counternick" mechanism of Mus81-Eme1 and for the nicked HJ to be the favored in vitro substrate of this enzyme.
+
The line below this paragraph, {{ABSTRACT_PUBMED_18413719}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 18413719 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_18413719}}
==About this Structure==
==About this Structure==
Line 41: Line 45:
[[Category: Phosphoprotein]]
[[Category: Phosphoprotein]]
[[Category: Polymorphism]]
[[Category: Polymorphism]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 30 13:31:13 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 12:37:29 2008''

Revision as of 09:37, 27 July 2008

Image:2ziu.png

Template:STRUCTURE 2ziu

Crystal structure of the Mus81-Eme1 complex

Template:ABSTRACT PUBMED 18413719

About this Structure

2ZIU is a Protein complex structure of sequences from Danio rerio and Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the Mus81-Eme1 complex., Chang JH, Kim JJ, Choi JM, Lee JH, Cho Y, Genes Dev. 2008 Apr 15;22(8):1093-106. PMID:18413719

Page seeded by OCA on Sun Jul 27 12:37:29 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2ziu"
Personal tools