1ni4

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[[Image:1ni4.gif|left|200px]]
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{{STRUCTURE_1ni4| PDB=1ni4 | SCENE= }}
{{STRUCTURE_1ni4| PDB=1ni4 | SCENE= }}
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'''HUMAN PYRUVATE DEHYDROGENASE'''
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===HUMAN PYRUVATE DEHYDROGENASE===
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==Overview==
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The derivative of vitamin B1, thiamin pyrophosphate, is a cofactor of enzymes performing catalysis in pathways of energy production. In alpha2beta2-heterotetrameric human pyruvate dehydrogenase, this cofactor is used to cleave the Calpha-C(=O) bond of pyruvate followed by reductive acetyl transfer to lipoyl-dihydrolipoamide acetyltransferase. The dynamic nonequivalence of two, otherwise chemically equivalent, catalytic sites has not yet been understood. To understand the mechanism of action of this enzyme, we determined the crystal structure of the holo-form of human pyruvate dehydrogenase at 1.95-A resolution. We propose a model for the flip-flop action of this enzyme through a concerted approximately 2-A shuttle-like motion of its heterodimers. Similarity of thiamin pyrophosphate binding in human pyruvate dehydrogenase with functionally related enzymes suggests that this newly defined shuttle-like motion of domains is common to the family of thiamin pyrophosphate-dependent enzymes.
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{{ABSTRACT_PUBMED_12651851}}
==About this Structure==
==About this Structure==
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[[Category: Pyruvate dehydrogenase]]
[[Category: Pyruvate dehydrogenase]]
[[Category: Thiamin pyrophosphate]]
[[Category: Thiamin pyrophosphate]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 12:38:15 2008''

Revision as of 09:38, 27 July 2008

Image:1ni4.png

Template:STRUCTURE 1ni4

HUMAN PYRUVATE DEHYDROGENASE

Template:ABSTRACT PUBMED 12651851

About this Structure

1NI4 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for flip-flop action of thiamin pyrophosphate-dependent enzymes revealed by human pyruvate dehydrogenase., Ciszak EM, Korotchkina LG, Dominiak PM, Sidhu S, Patel MS, J Biol Chem. 2003 Jun 6;278(23):21240-6. Epub 2003 Mar 21. PMID:12651851

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