2pd8

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{{STRUCTURE_2pd8| PDB=2pd8 | SCENE= }}
{{STRUCTURE_2pd8| PDB=2pd8 | SCENE= }}
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'''1.8 Angstrom Crystal Structure of the Cys71Ser mutant of Vivid'''
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===1.8 Angstrom Crystal Structure of the Cys71Ser mutant of Vivid===
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==Overview==
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The Neurospora crassa photoreceptor Vivid tunes blue-light responses and modulates gating of the circadian clock. Crystal structures of dark-state and light-state Vivid reveal a light, oxygen, or voltage Per-Arnt-Sim domain with an unusual N-terminal cap region and a loop insertion that accommodates the flavin cofactor. Photoinduced formation of a cystein-flavin adduct drives flavin protonation to induce an N-terminal conformational change. A cysteine-to-serine substitution remote from the flavin adenine dinucleotide binding site decouples conformational switching from the flavin photocycle and prevents Vivid from sending signals in Neurospora. Key elements of this activation mechanism are conserved by other photosensors such as White Collar-1, ZEITLUPE, ENVOY, and flavin-binding, kelch repeat, F-BOX 1 (FKF1).
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(as it appears on PubMed at http://www.pubmed.gov), where 17510367 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17510367}}
==About this Structure==
==About this Structure==
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[[Category: Lov domain]]
[[Category: Lov domain]]
[[Category: Photoreceptor]]
[[Category: Photoreceptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 12:53:50 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 12:41:54 2008''

Revision as of 09:42, 27 July 2008

Image:2pd8.png

Template:STRUCTURE 2pd8

1.8 Angstrom Crystal Structure of the Cys71Ser mutant of Vivid

Template:ABSTRACT PUBMED 17510367

About this Structure

2PD8 is a Single protein structure of sequence from Neurospora crassa. Full crystallographic information is available from OCA.

Reference

Conformational switching in the fungal light sensor Vivid., Zoltowski BD, Schwerdtfeger C, Widom J, Loros JJ, Bilwes AM, Dunlap JC, Crane BR, Science. 2007 May 18;316(5827):1054-7. PMID:17510367

Page seeded by OCA on Sun Jul 27 12:41:54 2008

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