2jpj

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{{STRUCTURE_2jpj| PDB=2jpj | SCENE= }}
{{STRUCTURE_2jpj| PDB=2jpj | SCENE= }}
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'''Lactococcin G-a in DPC'''
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===Lactococcin G-a in DPC===
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==Overview==
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The three-dimensional structures of the two peptides, lactococcin G-alpha (LcnG-alpha; contains 39 residues) and lactococcin G-beta (LcnG-beta, contains 35 residues), that constitute the two-peptide bacteriocin lactococcin G (LcnG) have been determined by nuclear magnetic resonance (NMR) spectroscopy in the presence of DPC micelles and TFE. In DPC, LcnG-alpha has an N-terminal alpha-helix (residues 3-21) that contains a GxxxG helix-helix interaction motif (residues 7-11) and a less well defined C-terminal alpha-helix (residues 24-34), and in between (residues 18-22) there is a second somewhat flexible GxxxG-motif. Its structure in TFE was similar. In DPC, LcnG-beta has an N-terminal alpha-helix (residues 6-19). The region from residues 20 to 35, which also contains a flexible GxxxG-motif (residues 18-22), appeared to be fairly unstructured in DPC. In the presence of TFE, however, the region between and including residues 23 and 32 formed a well defined alpha-helix. The N-terminal helix between and including residues 6 and 19 seen in the presence of DPC, was broken at residues 8 and 9 in the presence of TFE. The N-terminal helices, both in LcnG-alpha and -beta, are amphiphilic. We postulate that LcnG-alpha and -beta have a parallel orientation and interact through helix-helix interactions involving the first GxxxG (residues 7-11) motif in LcnG-alpha and the one (residues 18-22) in LcnG-beta, and that they thus lie in a staggered fashion relative to each other.
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(as it appears on PubMed at http://www.pubmed.gov), where 18187052 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18187052}}
==About this Structure==
==About this Structure==
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2JPJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Lactococcus_lactis Lactococcus lactis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JPJ OCA].
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2JPJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Lactococcus_lactis Lactococcus lactis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JPJ OCA].
==Reference==
==Reference==
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[[Category: Membrane bound]]
[[Category: Membrane bound]]
[[Category: Peptide]]
[[Category: Peptide]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:09:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 12:44:14 2008''

Revision as of 09:44, 27 July 2008

Image:2jpj.png

Template:STRUCTURE 2jpj

Lactococcin G-a in DPC

Template:ABSTRACT PUBMED 18187052

About this Structure

2JPJ is a Single protein structure of sequence from Lactococcus lactis. Full experimental information is available from OCA.

Reference

Three-dimensional structure of the two peptides that constitute the two-peptide bacteriocin lactococcin G., Rogne P, Fimland G, Nissen-Meyer J, Kristiansen PE, Biochim Biophys Acta. 2007 Dec 15;. PMID:18187052

Page seeded by OCA on Sun Jul 27 12:44:14 2008

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