2npa

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[[Image:2npa.gif|left|200px]]
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{{STRUCTURE_2npa| PDB=2npa | SCENE= }}
{{STRUCTURE_2npa| PDB=2npa | SCENE= }}
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'''the crystal structure of the human PPARaplpha ligand binding domain in complex with a a-hydroxyimino phenylpropanoic acid'''
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===the crystal structure of the human PPARaplpha ligand binding domain in complex with a a-hydroxyimino phenylpropanoic acid===
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==Overview==
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Oxime ethers of alpha-acyl-beta-phenylpropanoic acids were prepared to apply as PPARalpha and gamma dual agonists. Among them, compound 11l proved to exhibit potent in vitro activities with EC(50) of 19 and 13nM in PPARalpha and gamma, respectively. It showed better glucose lowering effects than rosiglitazone 1 and ameliorated the lipid profile like plasma triglyceride in db/db mice model.
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(as it appears on PubMed at http://www.pubmed.gov), where 17157019 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17157019}}
==About this Structure==
==About this Structure==
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[[Category: Protein-agonist complex]]
[[Category: Protein-agonist complex]]
[[Category: Transcription]]
[[Category: Transcription]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:44:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 12:46:35 2008''

Revision as of 09:46, 27 July 2008

Template:STRUCTURE 2npa

the crystal structure of the human PPARaplpha ligand binding domain in complex with a a-hydroxyimino phenylpropanoic acid

Template:ABSTRACT PUBMED 17157019

About this Structure

2NPA is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Design and synthesis of oxime ethers of alpha-acyl-beta-phenylpropanoic acids as PPAR dual agonists., Oon Han H, Kim SH, Kim KH, Hur GC, Joo Yim H, Chung HK, Ho Woo S, Dong Koo K, Lee CS, Sung Koh J, Kim GT, Bioorg Med Chem Lett. 2007 Feb 15;17(4):937-41. Epub 2006 Nov 18. PMID:17157019

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