1y77

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{{STRUCTURE_1y77| PDB=1y77 | SCENE= }}
{{STRUCTURE_1y77| PDB=1y77 | SCENE= }}
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'''Complete RNA Polymerase II elongation complex with substrate analogue GMPCPP'''
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===Complete RNA Polymerase II elongation complex with substrate analogue GMPCPP===
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==Overview==
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The crystal structure of the complete 12 subunit RNA polymerase (pol) II bound to a transcription bubble and product RNA reveals incoming template and nontemplate DNA, a seven base pair DNA/RNA hybrid, and three nucleotides each of separating DNA and RNA. The complex adopts the posttranslocation state and accommodates a cocrystallized nucleoside triphosphate (NTP) substrate. The NTP binds in the active site pore at a position to interact with a DNA template base. Residues surrounding the NTP are conserved in all cellular RNA polymerases, suggesting a universal mechanism of NTP selection and incorporation. DNA-DNA and DNA-RNA strand separation may be explained by pol II-induced duplex distortions. Four protein loops partition the active center cleft, contribute to embedding the hybrid, prevent strand reassociation, and create an RNA exit tunnel. Binding of the elongation factor TFIIS realigns RNA in the active center, possibly converting the elongation complex to an alternative state less prone to stalling.
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(as it appears on PubMed at http://www.pubmed.gov), where 15610738 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15610738}}
==About this Structure==
==About this Structure==
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[[Category: Substrate]]
[[Category: Substrate]]
[[Category: Transcription]]
[[Category: Transcription]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:57:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 12:55:07 2008''

Revision as of 09:55, 27 July 2008

Image:1y77.png

Template:STRUCTURE 1y77

Complete RNA Polymerase II elongation complex with substrate analogue GMPCPP

Template:ABSTRACT PUBMED 15610738

About this Structure

1Y77 is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Complete RNA polymerase II elongation complex structure and its interactions with NTP and TFIIS., Kettenberger H, Armache KJ, Cramer P, Mol Cell. 2004 Dec 22;16(6):955-65. PMID:15610738

Page seeded by OCA on Sun Jul 27 12:55:07 2008

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