1u5t

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{{STRUCTURE_1u5t| PDB=1u5t | SCENE= }}
{{STRUCTURE_1u5t| PDB=1u5t | SCENE= }}
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'''Structure of the ESCRT-II endosomal trafficking complex'''
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===Structure of the ESCRT-II endosomal trafficking complex===
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==Overview==
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The multivesicular-body (MVB) pathway delivers transmembrane proteins and lipids to the lumen of the endosome. The multivesicular-body sorting pathway has crucial roles in growth-factor-receptor downregulation, developmental signalling, regulation of the immune response and the budding of certain enveloped viruses such as human immunodeficiency virus. Ubiquitination is a signal for sorting into the MVB pathway, which also requires the functions of three protein complexes, termed ESCRT-I, -II and -III (endosomal sorting complex required for transport). Here we report the crystal structure of the core of the yeast ESCRT-II complex, which contains one molecule of the Vps protein Vps22, the carboxy-terminal domain of Vps36 and two molecules of Vps25, and has the shape of a capital letter 'Y'. The amino-terminal coiled coil of Vps22 and the flexible linker leading to the ubiquitin-binding NZF domain of Vps36 both protrude from the tip of one branch of the 'Y'. Vps22 and Vps36 form nearly equivalent interactions with the two Vps25 molecules at the centre of the 'Y'. The structure suggests how ubiquitinated cargo could be passed between ESCRT components of the MVB pathway through the sequential transfer of ubiquitinated cargo from one complex to the next.
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The line below this paragraph, {{ABSTRACT_PUBMED_15329733}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15329733 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15329733}}
==About this Structure==
==About this Structure==
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[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Trafficking]]
[[Category: Trafficking]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:47:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 12:56:48 2008''

Revision as of 09:56, 27 July 2008

Image:1u5t.png

Template:STRUCTURE 1u5t

Structure of the ESCRT-II endosomal trafficking complex

Template:ABSTRACT PUBMED 15329733

About this Structure

1U5T is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Structure of the ESCRT-II endosomal trafficking complex., Hierro A, Sun J, Rusnak AS, Kim J, Prag G, Emr SD, Hurley JH, Nature. 2004 Sep 9;431(7005):221-5. Epub 2004 Aug 25. PMID:15329733

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