1z3f

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[[Image:1z3f.gif|left|200px]]
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{{STRUCTURE_1z3f| PDB=1z3f | SCENE= }}
{{STRUCTURE_1z3f| PDB=1z3f | SCENE= }}
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'''Structure of ellipticine in complex with a 6-bp DNA'''
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===Structure of ellipticine in complex with a 6-bp DNA===
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==Overview==
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Ellipticine is a natural plant product that has been found to be a powerful anticancer drug. Although still unclear, its mechanism of action is considered to be mainly based on DNA intercalation and/or the inhibition of topoisomerase II. Many experimental data suggest an intercalation based on stacking interactions along the major base-pair axis, but alternative binding modes have been proposed, in particular for ellipticine derivatives. The 1.5 A resolution structure of ellipticine complexed to a 6 bp oligonucleotide unveils its mode of binding and enables a detailed analysis of the distorting effects of the drug on the DNA.
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The line below this paragraph, {{ABSTRACT_PUBMED_15983425}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15983425 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15983425}}
==About this Structure==
==About this Structure==
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[[Category: Ellipticine]]
[[Category: Ellipticine]]
[[Category: Intercalator]]
[[Category: Intercalator]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:08:07 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 12:59:01 2008''

Revision as of 09:59, 27 July 2008

Image:1z3f.png

Template:STRUCTURE 1z3f

Structure of ellipticine in complex with a 6-bp DNA

Template:ABSTRACT PUBMED 15983425

About this Structure

Full crystallographic information is available from OCA.

Reference

The anticancer agent ellipticine unwinds DNA by intercalative binding in an orientation parallel to base pairs., Canals A, Purciolas M, Aymami J, Coll M, Acta Crystallogr D Biol Crystallogr. 2005 Jul;61(Pt 7):1009-12. Epub 2005, Jun 24. PMID:15983425

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