2fxk

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{{STRUCTURE_2fxk| PDB=2fxk | SCENE= }}
{{STRUCTURE_2fxk| PDB=2fxk | SCENE= }}
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'''Crystal structure of the macro-domain of human core histone variant macroH2A1.1 (form A)'''
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===Crystal structure of the macro-domain of human core histone variant macroH2A1.1 (form A)===
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==Overview==
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Histone macroH2A is a hallmark of mammalian heterochromatin. Here we show that human macroH2A1.1 binds the SirT1-metabolite O-acetyl-ADP-ribose (OAADPR) through its macro domain. The 1.6-A crystal structure and mutants reveal how the metabolite is recognized. Mutually exclusive exon use in the gene H2AFY produces macroH2A1.2, whose tissue distribution differs. MacroH2A1.2 shows only subtle structural changes but cannot bind nucleotides. Alternative splicing may thus regulate the binding of nicotinamide adenine dinucleotide (NAD) metabolites to chromatin.
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(as it appears on PubMed at http://www.pubmed.gov), where 15965484 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15965484}}
==About this Structure==
==About this Structure==
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[[Category: Macro-domain]]
[[Category: Macro-domain]]
[[Category: P-loop]]
[[Category: P-loop]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:25:24 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:05:34 2008''

Revision as of 10:05, 27 July 2008

Image:2fxk.png

Template:STRUCTURE 2fxk

Crystal structure of the macro-domain of human core histone variant macroH2A1.1 (form A)

Template:ABSTRACT PUBMED 15965484

About this Structure

2FXK is a Single protein structure of sequence from Homo sapiens. This structure supersedes the now removed PDB entry 1zq0. Full crystallographic information is available from OCA.

Reference

Splicing regulates NAD metabolite binding to histone macroH2A., Kustatscher G, Hothorn M, Pugieux C, Scheffzek K, Ladurner AG, Nat Struct Mol Biol. 2005 Jul;12(7):624-5. Epub 2005 Jun 19. PMID:15965484

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