1z8l

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{{STRUCTURE_1z8l| PDB=1z8l | SCENE= }}
{{STRUCTURE_1z8l| PDB=1z8l | SCENE= }}
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'''Crystal structure of prostate-specific membrane antigen, a tumor marker and peptidase'''
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===Crystal structure of prostate-specific membrane antigen, a tumor marker and peptidase===
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==Overview==
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Prostate-specific membrane antigen (PSMA) is highly expressed in prostate cancer cells and nonprostatic solid tumor neovasculature and is a target for anticancer imaging and therapeutic agents. PSMA acts as a glutamate carboxypeptidase (GCPII) on small molecule substrates, including folate, the anticancer drug methotrexate, and the neuropeptide N-acetyl-l-aspartyl-l-glutamate. Here we present the 3.5-A crystal structure of the PSMA ectodomain, which reveals a homodimer with structural similarity to transferrin receptor, a receptor for iron-loaded transferrin that lacks protease activity. Unlike transferrin receptor, the protease domain of PSMA contains a binuclear zinc site, catalytic residues, and a proposed substrate-binding arginine patch. Elucidation of the PSMA structure combined with docking studies and a proposed catalytic mechanism provides insight into the recognition of inhibitors and the natural substrate N-acetyl-l-aspartyl-l-glutamate. The PSMA structure will facilitate development of chemotherapeutics, cancer-imaging agents, and agents for treatment of neurological disorders.
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The line below this paragraph, {{ABSTRACT_PUBMED_15837926}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15837926 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15837926}}
==About this Structure==
==About this Structure==
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[[Category: Thomas, L M.]]
[[Category: Thomas, L M.]]
[[Category: Dimeric protein with three domains of type a+b]]
[[Category: Dimeric protein with three domains of type a+b]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:18:54 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:07:25 2008''

Revision as of 10:07, 27 July 2008

Image:1z8l.png

Template:STRUCTURE 1z8l

Crystal structure of prostate-specific membrane antigen, a tumor marker and peptidase

Template:ABSTRACT PUBMED 15837926

About this Structure

1Z8L is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of prostate-specific membrane antigen, a tumor marker and peptidase., Davis MI, Bennett MJ, Thomas LM, Bjorkman PJ, Proc Natl Acad Sci U S A. 2005 Apr 26;102(17):5981-6. Epub 2005 Apr 18. PMID:15837926

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