This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3bu0

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:3bu0.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:3bu0.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_3bu0| PDB=3bu0 | SCENE= }}
{{STRUCTURE_3bu0| PDB=3bu0 | SCENE= }}
-
'''crystal structure of human ABH2 cross-linked to dsDNA with cofactors'''
+
===crystal structure of human ABH2 cross-linked to dsDNA with cofactors===
-
==Overview==
+
<!--
-
Escherichia coli AlkB and its human homologues ABH2 and ABH3 repair DNA/RNA base lesions by using a direct oxidative dealkylation mechanism. ABH2 has the primary role of guarding mammalian genomes against 1-meA damage by repairing this lesion in double-stranded DNA (dsDNA), whereas AlkB and ABH3 preferentially repair single-stranded DNA (ssDNA) lesions and can repair damaged bases in RNA. Here we show the first crystal structures of AlkB-dsDNA and ABH2-dsDNA complexes, stabilized by a chemical cross-linking strategy. This study reveals that AlkB uses an unprecedented base-flipping mechanism to access the damaged base: it squeezes together the two bases flanking the flipped-out one to maintain the base stack, explaining the preference of AlkB for repairing ssDNA lesions over dsDNA ones. In addition, the first crystal structure of ABH2, presented here, provides a structural basis for designing inhibitors of this human DNA repair protein.
+
The line below this paragraph, {{ABSTRACT_PUBMED_18432238}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 18432238 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_18432238}}
==About this Structure==
==About this Structure==
Line 35: Line 39:
[[Category: Oxidoreductase/dna complex]]
[[Category: Oxidoreductase/dna complex]]
[[Category: Protein/dna interaction]]
[[Category: Protein/dna interaction]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 11 10:57:31 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:13:33 2008''

Revision as of 10:13, 27 July 2008

Image:3bu0.png

Template:STRUCTURE 3bu0

crystal structure of human ABH2 cross-linked to dsDNA with cofactors

Template:ABSTRACT PUBMED 18432238

About this Structure

3BU0 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structures of DNA/RNA repair enzymes AlkB and ABH2 bound to dsDNA., Yang CG, Yi C, Duguid EM, Sullivan CT, Jian X, Rice PA, He C, Nature. 2008 Apr 24;452(7190):961-5. PMID:18432238

Page seeded by OCA on Sun Jul 27 13:13:33 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3bu0"
Personal tools