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2qdz

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{{STRUCTURE_2qdz| PDB=2qdz | SCENE= }}
{{STRUCTURE_2qdz| PDB=2qdz | SCENE= }}
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'''Structure of the membrane protein fhac: a member of the omp85/tpsb transporter family'''
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===Structure of the membrane protein fhac: a member of the omp85/tpsb transporter family===
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==Overview==
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In Gram-negative bacteria and eukaryotic organelles, beta-barrel proteins of the outer membrane protein 85-two-partner secretion B (Omp85-TpsB) superfamily are essential components of protein transport machineries. The TpsB transporter FhaC mediates the secretion of Bordetella pertussis filamentous hemagglutinin (FHA). We report the 3.15 A crystal structure of FhaC. The transporter comprises a 16-stranded beta barrel that is occluded by an N-terminal alpha helix and an extracellular loop and a periplasmic module composed of two aligned polypeptide-transport-associated (POTRA) domains. Functional data reveal that FHA binds to the POTRA 1 domain via its N-terminal domain and likely translocates the adhesin-repeated motifs in an extended hairpin conformation, with folding occurring at the cell surface. General features of the mechanism obtained here are likely to apply throughout the superfamily.
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The line below this paragraph, {{ABSTRACT_PUBMED_17702945}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17702945 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17702945}}
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
Structure of the membrane protein FhaC: a member of the Omp85-TpsB transporter superfamily., Clantin B, Delattre AS, Rucktooa P, Saint N, Meli AC, Locht C, Jacob-Dubuisson F, Villeret V, Science. 2007 Aug 17;317(5840):957-61. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17702945 17702945]
Structure of the membrane protein FhaC: a member of the Omp85-TpsB transporter superfamily., Clantin B, Delattre AS, Rucktooa P, Saint N, Meli AC, Locht C, Jacob-Dubuisson F, Villeret V, Science. 2007 Aug 17;317(5840):957-61. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17702945 17702945]
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Secretion signal of the filamentous haemagglutinin, a model two-partner secretion substrate., Hodak H, Clantin B, Willery E, Villeret V, Locht C, Jacob-Dubuisson F, Mol Microbiol. 2006 Jul;61(2):368-82. Epub 2006 Jun 12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16771844 16771844]
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Channel properties of TpsB transporter FhaC point to two functional domains with a C-terminal protein-conducting pore., Meli AC, Hodak H, Clantin B, Locht C, Molle G, Jacob-Dubuisson F, Saint N, J Biol Chem. 2006 Jan 6;281(1):158-66. Epub 2005 Nov 12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16284399 16284399]
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The crystal structure of filamentous hemagglutinin secretion domain and its implications for the two-partner secretion pathway., Clantin B, Hodak H, Willery E, Locht C, Jacob-Dubuisson F, Villeret V, Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):6194-9. Epub 2004 Apr 12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15079085 15079085]
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Novel topological features of FhaC, the outer membrane transporter involved in the secretion of the Bordetella pertussis filamentous hemagglutinin., Guedin S, Willery E, Tommassen J, Fort E, Drobecq H, Locht C, Jacob-Dubuisson F, J Biol Chem. 2000 Sep 29;275(39):30202-10. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10906141 10906141]
[[Category: Bordetella pertussis]]
[[Category: Bordetella pertussis]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Potra domain]]
[[Category: Potra domain]]
[[Category: Protein transport]]
[[Category: Protein transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 14:47:29 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:16:35 2008''

Revision as of 10:16, 27 July 2008

Image:2qdz.png

Template:STRUCTURE 2qdz

Structure of the membrane protein fhac: a member of the omp85/tpsb transporter family

Template:ABSTRACT PUBMED 17702945

About this Structure

2QDZ is a Single protein structure of sequence from Bordetella pertussis. Full crystallographic information is available from OCA.

Reference

Structure of the membrane protein FhaC: a member of the Omp85-TpsB transporter superfamily., Clantin B, Delattre AS, Rucktooa P, Saint N, Meli AC, Locht C, Jacob-Dubuisson F, Villeret V, Science. 2007 Aug 17;317(5840):957-61. PMID:17702945

Secretion signal of the filamentous haemagglutinin, a model two-partner secretion substrate., Hodak H, Clantin B, Willery E, Villeret V, Locht C, Jacob-Dubuisson F, Mol Microbiol. 2006 Jul;61(2):368-82. Epub 2006 Jun 12. PMID:16771844

Channel properties of TpsB transporter FhaC point to two functional domains with a C-terminal protein-conducting pore., Meli AC, Hodak H, Clantin B, Locht C, Molle G, Jacob-Dubuisson F, Saint N, J Biol Chem. 2006 Jan 6;281(1):158-66. Epub 2005 Nov 12. PMID:16284399

The crystal structure of filamentous hemagglutinin secretion domain and its implications for the two-partner secretion pathway., Clantin B, Hodak H, Willery E, Locht C, Jacob-Dubuisson F, Villeret V, Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):6194-9. Epub 2004 Apr 12. PMID:15079085

Novel topological features of FhaC, the outer membrane transporter involved in the secretion of the Bordetella pertussis filamentous hemagglutinin., Guedin S, Willery E, Tommassen J, Fort E, Drobecq H, Locht C, Jacob-Dubuisson F, J Biol Chem. 2000 Sep 29;275(39):30202-10. PMID:10906141

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