1jss

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Revision as of 16:25, 20 November 2007

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spinqualitylabelsall models 1jss, resolution 2.20Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Crystal structure of the Mus musculus cholesterol-regulated START protein 4 (StarD4).

Overview

The x-ray structure of the mouse cholesterol-regulated START protein 4, (StarD4) has been determined at 2.2-A resolution, revealing a compact, alpha/beta structure related to the START domain present in the, cytoplasmic C-terminal portion of human MLN64. The volume of the putative, lipid-binding tunnel was estimated at 847 A(3), which is consistent with, the binding of one cholesterol-size lipid molecule. Comparison of the, tunnel-lining residues in StarD4 and MLN64-START permitted identification, of possible lipid specificity determinants in both molecular tunnels., Homology modeling of related proteins, and comparison of the StarD4 and, MLN64-START structures, showed that StarD4 is a member of a large START, domain superfamily characterized by the helix-grip fold. Additional, mechanistic and evolutionary studies should be facilitated by the, availability of a second START domain structure from a distant relative of, MLN64.

About this Structure

1JSS is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the Mus musculus cholesterol-regulated START protein 4 (StarD4) containing a StAR-related lipid transfer domain., Romanowski MJ, Soccio RE, Breslow JL, Burley SK, Proc Natl Acad Sci U S A. 2002 May 14;99(10):6949-54. PMID:12011453

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