2irw

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[[Image:2irw.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_2irw| PDB=2irw | SCENE= }}
{{STRUCTURE_2irw| PDB=2irw | SCENE= }}
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'''Human 11-beta-Hydroxysteroid Dehydrogenase (HSD1) with NADP and Adamantane Ether Inhibitor'''
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===Human 11-beta-Hydroxysteroid Dehydrogenase (HSD1) with NADP and Adamantane Ether Inhibitor===
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==Overview==
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A novel class of adamantane ethers 11beta-hydroxysteroid hydrogenase type I inhibitors has been discovered. These compounds have excellent HSD-1 potency and selectivity against HSD-2. The structure-activity relationships, selectivity, metabolism, PK, ex vivo pharmacodynamic data, and an X-ray crystal structure of one of these inhibitors bound to h-HSD-1 are discussed.
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(as it appears on PubMed at http://www.pubmed.gov), where 17110106 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17110106}}
==Disease==
==Disease==
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[[Category: Nadp]]
[[Category: Nadp]]
[[Category: Oxidoreductase]]
[[Category: Oxidoreductase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:47:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:16:48 2008''

Revision as of 10:16, 27 July 2008

Image:2irw.png

Template:STRUCTURE 2irw

Contents

Human 11-beta-Hydroxysteroid Dehydrogenase (HSD1) with NADP and Adamantane Ether Inhibitor

Template:ABSTRACT PUBMED 17110106

Disease

Known disease associated with this structure: Cortisone reductase deficiency OMIM:[600713]

About this Structure

2IRW is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Discovery of adamantane ethers as inhibitors of 11beta-HSD-1: Synthesis and biological evaluation., Patel JR, Shuai Q, Dinges J, Winn M, Pliushchev M, Fung S, Monzon K, Chiou W, Wang J, Pan L, Wagaw S, Engstrom K, Kerdesky FA, Longenecker K, Judge R, Qin W, Imade HM, Stolarik D, Beno DW, Brune M, Chovan LE, Sham HL, Jacobson P, Link JT, Bioorg Med Chem Lett. 2007 Feb 1;17(3):750-5. Epub 2006 Oct 28. PMID:17110106

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