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1jad

From Proteopedia

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[[Image:1jad.gif|left|200px]]
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{{STRUCTURE_1jad| PDB=1jad | SCENE= }}
{{STRUCTURE_1jad| PDB=1jad | SCENE= }}
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'''C-terminal Domain of Turkey PLC-beta'''
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===C-terminal Domain of Turkey PLC-beta===
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==Overview==
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GTP-bound subunits of the Gq family of G alpha subunits directly activate phospholipase C-beta (PLC-beta) isozymes to produce the second messengers inositol 1,4,5-trisphosphate and diacylglycerol. PLC-betas are GTPase activating proteins (GAPs) that also promote the formation of GDP-bound, inactive G beta subunits. Both phospholipase activation by G alpha-GTP subunits and GAP activity require a C-terminal region unique to PLC-beta isozymes. The crystal structure of the C-terminal region from an avian PLC-beta, determined at 2.4 A resolution, reveals a novel fold composed almost entirely of three long helices forming a coiled-coil that dimerizes along its long axis in an antiparallel orientation. The dimer interface is extensive ( approximately 3,200 A(2)), and, based on gel exclusion chromatography, full length PLC-betas are dimeric, indicating that PLC-betas likely function as dimers. Sequence conservation, mutational data and molecular modeling show that an electrostatically positive surface of the dimer contains the major determinants for binding G beta q. Effector dimerization, as highlighted by PLC-betas, provides a viable mechanism for regulating signaling cascades linked to heterotrimeric G proteins.
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The line below this paragraph, {{ABSTRACT_PUBMED_11753430}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11753430 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11753430}}
==About this Structure==
==About this Structure==
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[[Category: Waldo, G L.]]
[[Category: Waldo, G L.]]
[[Category: Alpha helical coiled coil]]
[[Category: Alpha helical coiled coil]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:58:37 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:18:39 2008''

Revision as of 10:18, 27 July 2008

Image:1jad.png

Template:STRUCTURE 1jad

C-terminal Domain of Turkey PLC-beta

Template:ABSTRACT PUBMED 11753430

About this Structure

1JAD is a Single protein structure of sequence from Meleagris gallopavo. Full crystallographic information is available from OCA.

Reference

A unique fold of phospholipase C-beta mediates dimerization and interaction with G alpha q., Singer AU, Waldo GL, Harden TK, Sondek J, Nat Struct Biol. 2002 Jan;9(1):32-6. PMID:11753430

Page seeded by OCA on Sun Jul 27 13:18:39 2008

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