2adz

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[[Image:2adz.gif|left|200px]]
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{{STRUCTURE_2adz| PDB=2adz | SCENE= }}
{{STRUCTURE_2adz| PDB=2adz | SCENE= }}
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'''solution structure of the joined PH domain of alpha1-syntrophin'''
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===solution structure of the joined PH domain of alpha1-syntrophin===
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==Overview==
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Pleckstrin homology (PH) domains play diverse roles in cytoskeletal dynamics and signal transduction. Split PH domains represent a unique subclass of PH domains that have been implicated in interactions with complementary partial PH domains 'hidden' in many proteins. Whether partial PH domains exist as independent structural units alone and whether two halves of a split PH domain can fold together to form an intact PH domain are not known. Here, we solved the structure of the PH(N)-PDZ-PH(C) tandem of alpha-syntrophin. The split PH domain of alpha-syntrophin adopts a canonical PH domain fold. The isolated partial PH domains of alpha-syntrophin, although completely unfolded, remain soluble in solution. Mixing of the two isolated domains induces de novo folding and yields a stable PH domain. Our results demonstrate that two complementary partial PH domains are capable of binding to each other to form an intact PH domain. We further showed that the PH(N)-PDZ-PH(C) tandem forms a functionally distinct supramodule, in which the split PH domain and the PDZ domain function synergistically in binding to inositol phospholipids.
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{{ABSTRACT_PUBMED_16252003}}
==About this Structure==
==About this Structure==
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2ADZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ADZ OCA].
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2ADZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ADZ OCA].
==Reference==
==Reference==
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[[Category: Zhang, M.]]
[[Category: Zhang, M.]]
[[Category: Protein binding]]
[[Category: Protein binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:55:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:22:09 2008''

Revision as of 10:22, 27 July 2008

Image:2adz.png

Template:STRUCTURE 2adz

solution structure of the joined PH domain of alpha1-syntrophin

Template:ABSTRACT PUBMED 16252003

About this Structure

2ADZ is a Single protein structure of sequence from Mus musculus. Full experimental information is available from OCA.

Reference

Structure of the split PH domain and distinct lipid-binding properties of the PH-PDZ supramodule of alpha-syntrophin., Yan J, Wen W, Xu W, Long JF, Adams ME, Froehner SC, Zhang M, EMBO J. 2005 Dec 7;24(23):3985-95. Epub 2005 Oct 27. PMID:16252003

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