This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1jty
From Proteopedia
OCA (Talk | contribs)
(New page: 200px<br /><applet load="1jty" size="450" color="white" frame="true" align="right" spinBox="true" caption="1jty, resolution 2.97Å" /> '''Crystal structure of...)
Next diff →
Revision as of 16:27, 20 November 2007
|
Crystal structure of the multidrug binding transcriptional regulator QacR bound to ethidium
Overview
The Staphylococcus aureus multidrug binding protein QacR represses, transcription of the qacA multidrug transporter gene and is induced by, structurally diverse cationic lipophilic drugs. Here, we report the, crystal structures of six QacR-drug complexes. Compared to the DNA bound, structure, drug binding elicits a coil-to-helix transition that causes, induction and creates an expansive multidrug-binding pocket, containing, four glutamates and multiple aromatic and polar residues. These structures, indicate the presence of separate but linked drug-binding sites within a, single protein. This multisite drug-binding mechanism is consonant with, studies on multidrug resistance transporters.
About this Structure
1JTY is a Single protein structure of sequence from Staphylococcus aureus with ET and SO4 as ligands. Full crystallographic information is available from OCA.
Reference
Structural mechanisms of QacR induction and multidrug recognition., Schumacher MA, Miller MC, Grkovic S, Brown MH, Skurray RA, Brennan RG, Science. 2001 Dec 7;294(5549):2158-63. PMID:11739955
Page seeded by OCA on Tue Nov 20 18:34:34 2007
