1okk

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{{STRUCTURE_1okk| PDB=1okk | SCENE= }}
{{STRUCTURE_1okk| PDB=1okk | SCENE= }}
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'''HOMO-HETERODIMERIC COMPLEX OF THE SRP GTPASES'''
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===HOMO-HETERODIMERIC COMPLEX OF THE SRP GTPASES===
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==Overview==
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Two structurally homologous guanosine triphosphatase (GTPase) domains interact directly during signal recognition particle (SRP)-mediated cotranslational targeting of proteins to the membrane. The 2.05 angstrom structure of a complex of the NG GTPase domains of Ffh and FtsY reveals a remarkably symmetric heterodimer sequestering a composite active site that contains two bound nucleotides. The structure explains the coordinate activation of the two GTPases. Conformational changes coupled to formation of their extensive interface may function allosterically to signal formation of the targeting complex to the signal-sequence binding site and the translocon. We propose that the complex represents a molecular "latch" and that its disengagement is regulated by completion of assembly of the GTPase active site.
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(as it appears on PubMed at http://www.pubmed.gov), where 14726591 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14726591}}
==About this Structure==
==About this Structure==
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[[Category: Signal sequence recognition]]
[[Category: Signal sequence recognition]]
[[Category: Srp]]
[[Category: Srp]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:58:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:28:43 2008''

Revision as of 10:28, 27 July 2008

Image:1okk.png

Template:STRUCTURE 1okk

HOMO-HETERODIMERIC COMPLEX OF THE SRP GTPASES

Template:ABSTRACT PUBMED 14726591

About this Structure

1OKK is a Protein complex structure of sequences from Thermus aquaticus. Full crystallographic information is available from OCA.

Reference

Heterodimeric GTPase core of the SRP targeting complex., Focia PJ, Shepotinovskaya IV, Seidler JA, Freymann DM, Science. 2004 Jan 16;303(5656):373-7. PMID:14726591

Page seeded by OCA on Sun Jul 27 13:28:43 2008

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