1ogq

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{{STRUCTURE_1ogq| PDB=1ogq | SCENE= }}
{{STRUCTURE_1ogq| PDB=1ogq | SCENE= }}
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'''THE CRYSTAL STRUCTURE OF PGIP (POLYGALACTURONASE INHIBITING PROTEIN), A LEUCINE RICH REPEAT PROTEIN INVOLVED IN PLANT DEFENSE'''
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===THE CRYSTAL STRUCTURE OF PGIP (POLYGALACTURONASE INHIBITING PROTEIN), A LEUCINE RICH REPEAT PROTEIN INVOLVED IN PLANT DEFENSE===
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==Overview==
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Polygalacturonase-inhibiting proteins (PGIPs) are plant cell wall proteins that protect plants from fungal invasion. They interact with endopolygalacturonases secreted by phytopathogenic fungi, inhibit their enzymatic activity, and favor the accumulation of oligogalacturonides, which activate plant defense responses. PGIPs are members of the leucine-rich repeat (LRR) protein family that in plants play crucial roles in development, defense against pathogens, and recognition of beneficial microbes. Here we report the crystal structure at 1.7-A resolution of a PGIP from Phaseolus vulgaris. The structure is characterized by the presence of two beta-sheets instead of the single one originally predicted by modeling studies. The structure also reveals a negatively charged surface on the LRR concave face, likely involved in binding polygalacturonases. The structural information on PGIP provides a basis for designing more efficient inhibitors for plant protection.
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{{ABSTRACT_PUBMED_12904578}}
==About this Structure==
==About this Structure==
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[[Category: Inhibitor]]
[[Category: Inhibitor]]
[[Category: Polygalacturonase inhibiting protein]]
[[Category: Polygalacturonase inhibiting protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:49:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:29:25 2008''

Revision as of 10:29, 27 July 2008

Image:1ogq.png

Template:STRUCTURE 1ogq

THE CRYSTAL STRUCTURE OF PGIP (POLYGALACTURONASE INHIBITING PROTEIN), A LEUCINE RICH REPEAT PROTEIN INVOLVED IN PLANT DEFENSE

Template:ABSTRACT PUBMED 12904578

About this Structure

1OGQ is a Single protein structure of sequence from Phaseolus vulgaris. Full crystallographic information is available from OCA.

Reference

The crystal structure of polygalacturonase-inhibiting protein (PGIP), a leucine-rich repeat protein involved in plant defense., Di Matteo A, Federici L, Mattei B, Salvi G, Johnson KA, Savino C, De Lorenzo G, Tsernoglou D, Cervone F, Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):10124-8. Epub 2003 Aug 6. PMID:12904578

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