1wcy

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{{STRUCTURE_1wcy| PDB=1wcy | SCENE= }}
{{STRUCTURE_1wcy| PDB=1wcy | SCENE= }}
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'''Crystal Structure Of Human Dipeptidyl Peptidase IV (DPPIV) Complex With Diprotin A'''
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===Crystal Structure Of Human Dipeptidyl Peptidase IV (DPPIV) Complex With Diprotin A===
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==Overview==
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Dipeptidyl peptidase IV (DPPIV) is a serine protease, a member of the prolyl oligopeptidase (POP) family, and has been implicated in several diseases. Therefore, it seems important to develop selective inhibitors for human DPPIV (hDPPIV) that are able to control the biological function of hDPPIV. In order to elucidate the binding mode and substrate specificity, we determined the crystal structure complex of hDPPIV and diprotin A (IIe-Pro-IIe), a slowly hydrolyzed substrate of hDPPIV, at 2.2 A resolution. In this paper, we discuss the molecular interaction mechanism of diprotin A with hDPPIV based on the X-ray crystal structure.
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{{ABSTRACT_PUBMED_15255191}}
==About this Structure==
==About this Structure==
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[[Category: Prolyl oligopeptidase]]
[[Category: Prolyl oligopeptidase]]
[[Category: Serine protease]]
[[Category: Serine protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:29:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:31:26 2008''

Revision as of 10:31, 27 July 2008

Image:1wcy.png

Template:STRUCTURE 1wcy

Crystal Structure Of Human Dipeptidyl Peptidase IV (DPPIV) Complex With Diprotin A

Template:ABSTRACT PUBMED 15255191

About this Structure

1WCY is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The crystal structure of human dipeptidyl peptidase IV (DPPIV) complex with diprotin A., Hiramatsu H, Yamamoto A, Kyono K, Higashiyama Y, Fukushima C, Shima H, Sugiyama S, Inaka K, Shimizu R, Biol Chem. 2004 Jun;385(6):561-4. PMID:15255191

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