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2oqo

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[[Image:2oqo.gif|left|200px]]
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{{STRUCTURE_2oqo| PDB=2oqo | SCENE= }}
{{STRUCTURE_2oqo| PDB=2oqo | SCENE= }}
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'''Crystal structure of a peptidoglycan glycosyltransferase from a class A PBP: insight into bacterial cell wall synthesis'''
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===Crystal structure of a peptidoglycan glycosyltransferase from a class A PBP: insight into bacterial cell wall synthesis===
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==Overview==
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Peptidoglycan is an essential polymer that forms a protective shell around bacterial cell membranes. Peptidoglycan biosynthesis is the target of many clinically used antibiotics, including the beta-lactams, imipenems, cephalosporins, and glycopeptides. Resistance to these and other antibiotics has prompted interest in an atomic-level understanding of the enzymes that make peptidoglycan. Representative structures have been reported for most of the enzymes in the pathway. Until now, however, there have been no structures of any peptidoglycan glycosyltransferases (also known as transglycosylases), which catalyze formation of the carbohydrate chains of peptidoglycan from disaccharide subunits on the bacterial cell surface. We report here the 2.1-A crystal structure of the peptidoglycan glycosyltransferase (PGT) domain of Aquifex aeolicus PBP1A. The structure has a different fold from all other glycosyltransferase structures reported to date, but it bears some resemblance to lambda-lysozyme, an enzyme that degrades the carbohydrate chains of peptidoglycan. An analysis of the structure, combined with biochemical information showing that these enzymes are processive, suggests a model for glycan chain polymerization.
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(as it appears on PubMed at http://www.pubmed.gov), where 17360321 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17360321}}
==About this Structure==
==About this Structure==
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[[Category: Yuan, Y.]]
[[Category: Yuan, Y.]]
[[Category: Transferase]]
[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 11:28:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:32:45 2008''

Revision as of 10:32, 27 July 2008

Image:2oqo.png

Template:STRUCTURE 2oqo

Crystal structure of a peptidoglycan glycosyltransferase from a class A PBP: insight into bacterial cell wall synthesis

Template:ABSTRACT PUBMED 17360321

About this Structure

2OQO is a Single protein structure of sequence from Aquifex aeolicus. Full crystallographic information is available from OCA.

Reference

Crystal structure of a peptidoglycan glycosyltransferase suggests a model for processive glycan chain synthesis., Yuan Y, Barrett D, Zhang Y, Kahne D, Sliz P, Walker S, Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5348-53. Epub 2007 Mar 8. PMID:17360321

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