3bes

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:3bes.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:3bes.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_3bes| PDB=3bes | SCENE= }}
{{STRUCTURE_3bes| PDB=3bes | SCENE= }}
-
'''Structure of a Poxvirus ifngbp/ifng Complex'''
+
===Structure of a Poxvirus ifngbp/ifng Complex===
-
==Overview==
+
<!--
-
Ectromelia virus (ECTV) encodes an IFN-gamma-binding protein (IFN-gammaBP(ECTV)) that disrupts IFN-gamma signaling and its ability to induce an antiviral state within cells. IFN-gammaBP(ECTV) is an important virulence factor that is highly conserved (&gt;90%) in all orthopoxviruses, including variola virus, the causative agent of smallpox. The 2.2-A crystal structure of the IFN-gammaBP(ECTV)/IFN-gamma complex reveals IFN-gammaBP(ECTV) consists of an IFN-gammaR1 ligand-binding domain and a 57-aa helix-turn-helix (HTH) motif that is structurally related to the transcription factor TFIIA. The HTH motif forms a tetramerization domain that results in an IFN-gammaBP(ECTV)/IFN-gamma complex containing four IFN-gammaBP(ECTV) chains and two IFN-gamma dimers. The structure, combined with biochemical and cell-based assays, demonstrates that IFN-gammaBP(ECTV) tetramers are required for efficient IFN-gamma antagonism.
+
The line below this paragraph, {{ABSTRACT_PUBMED_18252829}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 18252829 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_18252829}}
==Disease==
==Disease==
Line 37: Line 41:
[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Receptor]]
[[Category: Receptor]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:41:44 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:41:16 2008''

Revision as of 10:41, 27 July 2008

Image:3bes.png

Template:STRUCTURE 3bes

Contents

Structure of a Poxvirus ifngbp/ifng Complex

Template:ABSTRACT PUBMED 18252829

Disease

Known disease associated with this structure: AIDS, rapid progression to OMIM:[147570], Aplastic anemia OMIM:[147570], Interferon, immune, deficiency OMIM:[147570], Hepatitis C virus, resistance to OMIM:[147570], TSC2 angiomyolipomas, renal, modifier of OMIM:[147570], Tuberculosis, susceptibility to OMIM:[147570]

About this Structure

3BES is a Protein complex structure of sequences from Ectromelia virus and Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure and mechanism of IFN-gamma antagonism by an orthopoxvirus IFN-gamma-binding protein., Nuara AA, Walter LJ, Logsdon NJ, Yoon SI, Jones BC, Schriewer JM, Buller RM, Walter MR, Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):1861-6. Epub 2008 Feb 5. PMID:18252829

Page seeded by OCA on Sun Jul 27 13:41:16 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3bes"
Personal tools