1ow6

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{{STRUCTURE_1ow6| PDB=1ow6 | SCENE= }}
{{STRUCTURE_1ow6| PDB=1ow6 | SCENE= }}
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'''Paxillin LD4 motif bound to the Focal Adhesion Targeting (FAT) domain of the Focal Adhesion Kinase'''
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===Paxillin LD4 motif bound to the Focal Adhesion Targeting (FAT) domain of the Focal Adhesion Kinase===
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==Overview==
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Focal adhesions (FAs) are large submembrane signaling complexes formed at sites of cellular attachment to the extracellular matrix. The interaction of LD motifs with their targets plays an important role in the assembly of FAs. We have determined the molecular basis for the recognition of two paxillin LD motifs by the FA targeting (FAT) domain of FA kinase using a combination of X-ray crystallography, solution NMR, and homology modeling. The four-helix FAT domain displays two LD binding sites on opposite sites of the molecule that bind LD peptides in a helical conformation. Threading studies suggest that the LD-interacting domain of p95PKL shares a common four-helical core with the FAT domain and the tail of vinculin, defining a structural family of LD motif binding modules.
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(as it appears on PubMed at http://www.pubmed.gov), where 14527389 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14527389}}
==About this Structure==
==About this Structure==
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[[Category: Amphiphatic helix]]
[[Category: Amphiphatic helix]]
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[[Category: Domain swapping]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:20:57 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:44:13 2008''

Revision as of 10:44, 27 July 2008

Image:1ow6.png

Template:STRUCTURE 1ow6

Paxillin LD4 motif bound to the Focal Adhesion Targeting (FAT) domain of the Focal Adhesion Kinase

Template:ABSTRACT PUBMED 14527389

About this Structure

1OW6 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Molecular recognition of paxillin LD motifs by the focal adhesion targeting domain., Hoellerer MK, Noble ME, Labesse G, Campbell ID, Werner JM, Arold ST, Structure. 2003 Oct;11(10):1207-17. PMID:14527389

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